By Irfana Parveen

B.Sc (Psychiatry Ward)

29 April 2022
Medically reviewed by
Sumayya Salam
Pharm D
Table of Contents

Anxiety is a natural substance to your body. Every 10 in 1 person suffers due to low-income family surroundings, stressful jobs, workplace pressure, or financial issues. There are no exact causes of Anxiety. Researchers believe that genetic and environmental factors play a significant role in stress development in the person.

About 31% of people in the US are estimated to suffer from Anxiety disorders. People with untreated Anxiety will lead to developing some the factors like ongoing depression, stress, and suicidal thoughts, so it is essential to look after these concerns.

Several medications are available to treat Anxiety. Ativan is a benzodiazepine drug that helps treat Anxiety. While contacting your doctors, you can consume and start using it. Let us see detail about the drug.

What is Ativan?

Ativan, also known as Lorazepam, belongs to the group of benzodiazepine drugs. Which usually have the properties of sedative agents to produce a calming and relaxing agent. 

Ativan is used to treat Anxiety, panic, and seizure disorders. It is also used in the treatment of people with alcohol withdrawal. It is classified as an IV schedule drug, lower in drug abuse and addiction. 

How Does Ativan Work?

Ativan works in the central nervous system with the help of neurotransmitters in the brain known as gamma-aminobutyric acid receptors (GABA). It is responsible for regulating sleep functions and relaxing the anxiety level. 

Therefore the drug acts on the receptors to slow down the CNS. This helps reduce the excess agitation and excitement in the brain and induces a calming agent. Thus the CNS will be depressed, Ativan will be able to lessen the intensity of Anxiety and panic attacks, and it will be more effective in treating the symptoms. The drug enters and last in your system for up to more extended hours.

How Long Does It Take To Feel The Effects?

Drugs like benzodiazepines, such as Ativan, have the effects of sedatives and hypnotics. It has the function of enhancing the natural chemical substance called GABA,  which depresses the central nervous system in our brain. This results in calming and relaxing agents. 

The drug Ativan comes in liquid, tablets, and injections. All the routes have different schedules when they have to be taken when you are taking pills or drinking; the effects will be shown after 2 hours. An injection will take 15 to 30 minutes and last up to 12 to 24 hours. 

The maximum dosage of the drug is 10mg per day; it can be given in divided doses of 2 to 6mg but not more than 10mg in 24 hours.
Many Ativan users will develop increased anxiety when they suddenly stop using the drug, leading to Ativan's rebound.
Ativan is a prescribed drug; you need a prescription to buy the medicine. It is available in online stores before purchasing. Just check trusted websites.

How Long Does Ativan Last In Your System?

Ativan is the first-acting drug which means it has a longer half-life. The half-life is about 12 hours, meaning it will decrease the concentration in the body by half every 12 hours. Usually, the drug will be metabolized in your liver and eliminated from the body with the help of the kidney through urine. The drug may be present up to  9 days after the last use. Let us see about some of the specific areas,

How Long Does Ativan Last In Your Blood?

The blood test is detected 6 hours after the ingestion; even blood tests can be seen three days after the last use. It may be longer for people taking higher doses of Ativan.

How Long Does Ativan Last In Your Urine?

In the urine tests, it stays up to 6 weeks. It usually depends on how much you have taken the drug and for how long. In urine, screening tests can also detect that the Ativan samples can stay up to 6 weeks after the last use. 

How Long Does Ativan Last In Your Hair?

Hair samples are sent to the lab after the hair screening test. In hair tests, it can be detected up to 12 days after the last use of the drug. For more extended use of the drug, it can take much longer days after the previous use.

How Long Does Ativan Last In Your saliva?

It is used in rare cases; in the saliva test, it is detected that the samples can stay up to 8 hours after the last use.

What Factors Affect Detection Time?

Usually, all the drugs have some specific period of drug detection in your system. Ativan also influences and remains in the person's system. Some of the biological factors are included to detect how long Ativan stays in the design, such as,


Older People have less potential to clear the drug when compared with younger ones due to the decreased function of organs, lower blood flow, or any other health issues that can affect the older people's health by how long the drug is processed and excreted

Kidney function:  

Researchers say liver impairment does not impact Ativan's clearance rate. It usually depends on kidney problems associated with prolonged drug half-life.

Genetic factors: 

The presence of liver enzymes and kidney function will significantly affect how the drug breaks into the body. 


People with short and small structured bodies usually take time to clear the Ativan from their bodies comparatively slower than tall and heavy structured bodies. Ativan may stay longer in your system with a person who is overweight.

Frequency use: 

If you are taking a higher dosage of Ativan, it takes time to metabolize in your body, so it will differ from one to another according to the frequency you are taking the drug

Use of other substances: 

Consuming other substances impacts how quickly the drug is processed and excreted from the body. For example, if you drink alcohol with the medicine, the clearance rate will be 18%. Hence, the researcher says taking medications with alcohol will impact the body because it will slow the processed metabolism process.

How To Get Ativan Out Of Your System? 

Like other benzodiazepines, Ativan has a long half-life; it will lead to physical dependence and develop withdrawal symptoms when you stop using the drug. When you decide to stop the medication, get medical advice from your doctor. If you see someone using the medicine for a long time, you have to speed up quickly to clear the drugs from your system so that the drug is excreted in the urine. So being hydrated and drinking plenty of water will help remove it.

Half-life Of Ativan:

It depends upon factors like age, weight, size, and how much you take the drug. A kidney function test shows that Ativan has 14 hours of life. The amount of time it brings into the individual system metabolizes the cure to its initial concentration by the body every half 14 hours until the kidney eliminates it in the urine. Younger people will have more clearance rates than older adults.

Can Ativan be abused/addicted/ overdosed:

In a schedule of IV drugs, Ativan considers drug abuse. Taking medicine for a long time can lead to physical and psychological dependence affecting the person with the story of abuse. Mental health disorders are persons likely to struggle with at one abuse.


Ativan leads to addiction, in which the individual develops more dependence on the drug and develops withdrawal symptoms; it makes it hard for the person suffering from substance use disorder to stop using the medicine. Some of the problems associated are, 

  • Withdrawal from family and friends
  • Not showing interest in school, workplace
  • Attempting dangerous activities
  • Being isolating alone
  • Financial issues 


When a person overdoses on a drug, they are under a high warning. The doctor will prescribe them the recommended dosage. If you overdose on drugs  like benzodiazepine, it will lead to suffering from side effects like 

  • Excessive drowsiness 
  • Sweating
  • Memory loss
  • Respiratory depression 
  • Lethargy

If someone is experiencing this symptom for a more extended period, you should visit your doctor immediately and seek medical attention.

Withdrawal symptoms of Ativan?

After using for a short period, Ativan leads to a physical addiction to the person; even withdrawal symptoms are common when a person goes through the drug. It is more possible to develop withdrawal symptoms even if you use it for a short time, such as, 

  • Sweating
  • Headache
  • Anxiety
  • Insomnia
  • Irritability
  • Seizure
  • Muscle spasms
  • Increased heart rate

What are the side effects?

Side effects are common in drugs if you face prolonged effects like a severe allergic reaction to the medication, difficulty breathing, swelling, hives, etc. Ativan can lead slow or stop your breathing level in the case if you are using opioid medicines or alcohol. Visit your doctor if you face symptoms like,

  • severe drowsiness;
  • sleep problems;
  • Confusion
  • Suicidal thoughts
  • Restless
  • Hallucinations
  • Vision changes 
  • Changes in mood or behavior
  • Talkative
  • Dizziness
  • Weakness 
  • Unsteadiness

If you face any side effects for longer, call your doctor immediately and ask for help. 

Precautions that should be taken while consuming Ativan? 

Ativan is a long-acting drug that can stay up to several long in your system. If you are taking alcohol, it will lead the drug into dangerous effects. When you mix, it can lead to the following symptoms, 
Both are depressants, leading to extreme drowsiness, breathing issues, and coma. So you have to check with your doctor if you are an alcoholic.

  • If breastfeeding your baby, be aware that the milk passes into your breast milk and affects your baby.
  • If you plan to get pregnant or be pregnant, speak with your doctor.
  • If you feel depressed or have any suicidal thoughts, avoid taking the drug Ativan.
  • If you are an older adult, talk with your doctor because it will affect more older people to have extreme drowsiness. 
  • Be aware of the drug side effects. While taking the pill, it will help to caution yourself to avoid dangerous activities. 

Drug interaction Ativan

Drug interaction with Ativan can lead to severe effects. You should always be aware before mixing another drug with Ativan. If you use any of the below-mentioned medications, speak to your doctor. Your doctor will help you to adjust your dosage and cooperate between both drugs. Drugs you should not mix with Ativan are:

  • Antihistamines drugs
  • Antipsychotics drugs
  • Narcotic pain drugs 
  • Oral antifungals
  • Oral contraceptives 
  • Any Sedatives
  • Tranquilizers, 
  • Any  sleeping pills
  • Pain medications 

Bottom line from Practical Anxiety Solution

So far now, You must have come to an understanding about the drug Ativan. Ativan is used to treat Anxiety and seizure disorder. It is very effective in treating Anxiety and seizure attacks by producing calming and relaxing agents in the CNS in your brain.
This is available only after the prescription from your doctor; if you are willing to buy it online, refer to trusted sources. It may have side effects, so talk to your doctor about your medical history before using the drug.

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