Published on 22 November 2021

Treating Pain with Celexa: What You Should Know?

Citalopram (Celexa) DefaultImage
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Celexa is a prescription medicine. Celexa is a medication that is used to treat depression in adults. Depression is a type of mood disorder in which you feel down and lose interest in things you used to enjoy.

Celexa is an antidepressant that contains the active ingredient citalopram. Celexa is available as a pill to be taken once a day.

Obsessive-compulsive disorder, generalized anxiety disorder, panic disorder, social phobia (also known as social anxiety disorder), posttraumatic stress disorder, eating disorders such as binge eating disorder, and premenstrual dysphoric disorder may all benefit from citalopram when used "off-label" (PMDD).

Drugs intended to treat other conditions are some of the most effective and widely used treatments for chronic pain. Antidepressants, despite not being explicitly designed to treat chronic pain, are a cornerstone in the treatment of many chronic pain syndromes, even when depression isn't a problem.

Antidepressants appear to be the most effective treatment for pain caused by:

  • Arthritis.
  • Pain in the nerves.
  • Headache caused by tension.
  • Migraine.
  • Nerve damage from diabetes. 
  • Nerve damage from shingles.
  • Pain in the face.
  • Fibromyalgia.
  • Low backache.
  • Pelvic discomfort.
  • Pain from Multiple sclerosis.

The mechanism by which these medications relieve pain is currently unknown. Antidepressants may enhance pain-reducing neurotransmitters in the spinal cord. However, they do not function right away. An antidepressant may provide some relief after a week or two, but optimum improvement may take several weeks. Antidepressants provide moderate pain alleviation for most people.

If pain treatment with antidepressants is insufficient, drugs from other pharmacological classes with different mechanisms of pain reduction (such as anticonvulsants) may be used in combination with antidepressant class pharmaceuticals. It's worth noting that antidepressant medicines have been linked to a modest increase in the risk of suicidal thoughts or behaviors. If you're depressed or suicidal, see a doctor or counselor right away (Divin, A.L., 2012).

How Effective Is Celexa For Pain?

Celexa is a part of a class of drugs known as selective serotonin reuptake inhibitors (SSRIs). Selective serotonin reuptake inhibitors (SSRIs) work by preventing serotonin from being reabsorbed into the brain. Compared to tricyclic antidepressants, the data on selective serotonin reuptake inhibitors (SSRIs) in treating neuropathic pain is less consistent, and studies are far fewer. Citalopram has shown little efficacy in the treatment of neuropathic pain to date.

The overall impression is that in the treatment of neuropathic pain, Selective serotonin reuptake inhibitors (SSRIs) are thought to be less successful than other antidepressant alternatives. Indeed, it appears that SSRIs are not superior to other types of antidepressants used in the treatment of neuropathic pain, such as tricyclic antidepressants, from a conservative standpoint. While the majority of Selective serotonin reuptake inhibitors (SSRI) side effects are minor, there is a risk of weight gain with long-term usage and sexual dysfunction and withdrawal symptoms with abrupt termination (Lindsay, T.J., 2016).