Published on 21 September 2022

How Long Does Ambien Stay in Your System

Table of Contents

Sleeplessness or inability to sleep during nighttime is called insomnia, a prevalent condition spreading all over people. While you face severe symptoms like lack of sleep, you may consult your doctor and seek medical attention immediately. 

Especially in the USA, approximately 50-70 million people suffer from sleep disorders. So when it comes to treating such conditions, there are two ways: natural or medicines. There are various medicines available that can treat sleep disorders.

Ambien is one of the sleeping pills that help to deal with sleep disorders. Knowing how long a medicine will be in your system is essential. Know more about it in detail.

What Is Ambien?

Ambien comes under the category of the "Z" group of drugs. It works very effectively in treating mania. Ambien is the most frequently prescribed medicine for sleeplessness and is suggested for short-term use to help with insomnia.

Zolpidem, its generic medicine, eszopiclone, and zaleplon, fall into the category of "z-drugs" due to their chemical name and pronunciation. To buy Zolpidem, you need to visit a legit pharmacy followed by a prescription from a doctor.

How Does Ambien Work?

Ambien binds to the central benzodiazepine receptors of the omega-1 subtype, the α1-containing GABAA receptors, found primarily in the brain. GABA blocks specific brain activity and increases brain inhibition to induce sleep. 

Ambien is a Schedule IV substance but has some potential for Abuse and physical dependence. According to data from the Substance Abuse and Mental Health Services Administration (SAMHSA), roughly 9.5 million reported taking Ambien products in the previous year, and about 900,000 people misused the medication.

How Long Does Ambien Stay In Your System?

The rate at which a drug is eliminated from the body varies from person to person depending on factors like age, weight, medications, any underlying medical conditions, and kidney and liver function. 

Ambien is a non-benzodiazepine drug for the short-term treatment of insomnia. By using a half-life, we can determine the time it takes to eliminate the drug from the body.

Ambien Half-Life

Any medicine you consume will take off from your body. The half-life of Ambien is two to three hours, which is short. In healthy humans, the medication has a half-life of around 2.6 hours. So, roughly two and a half hours after taking a dose of Ambien, the body will have cleared half of it. Ambien may require between 11 to 16.5 hours to be eliminated from the body.

Factors Affecting How Long Ambien Stays In Your System

Any medicine you take will stay in your body for a specific period. After that time, your body will wash off the drug. It all depends on various factors of the human body, such as:

Age: Ambien should linger in the blood for 30% longer in older persons. With age, Ambien metabolism slows.

Body mass and percentage of body fat are individual factors that can influence how soon Ambien departs the body.

Dosage: A person's dosage may impact how rapidly a substance is metabolized. It takes longer for the body to clear itself of them for higher.

Frequency of use: Frequent use of Ambien results in the accumulation of the drug in the body. It takes longer to metabolize and eliminate from the body.

Organ function: People with kidney or liver issues can anticipate having Ambien in their systems for longer.

Sex: Women process Ambien around 45% more slowly than men.

Does Ambien Show Up on a Drug Test?

Detection of Ambien levels in blood or urine is helpful for toxicology and routine drug misuse monitoring. The detection window for therapeutic doses in urine is between 24 and 48 hours, and it is likely to be extended in cases of overdose or poisoning. 

Frequently Asked Questions

Ambien should be used for at least 3 to 4 weeks because it may develop serious side effects like hallucinations, dizziness, nausea, and irritability. You should consult with your doctor to avoid the withdrawal effects.
Ambien leads to dangerous effects, which may result in severe symptoms of abnormal behavior changes like suicidal thoughts and memory impairment.
In urine, it may remain up to 72 hours after the last dose; in hair, up to detectable following 90 days; and in saliva, it will stay about 8 hours after intake of the drug.

How long does Ambien remain in the blood?

  • Ambien concentrations in blood or plasma are between 30-300 g/l in patients receiving the medication therapeutically, 100-700 g/l in drivers arrested for driving under the influence, and 1000-7000 g/l in patients experiencing an acute overdose. 
  • It takes 1.6 hours to reach peak levels of Ambien in the blood after someone takes it.
  • After consuming the medication, it takes 30 minutes to detect Ambien in the blood.
  • In healthy male adults, Ambien stays in the blood for about 12.5 hours, which takes about five half-lives for a drug to eliminate from the body.

How long does Ambien remain in the urine?

  • Up to 72 hours, or three days, following the last dose, the use of Ambien may still be detectable in a urine sample.
  • When taking a dose of Ambien, someone who is well-hydrated is likely to have higher urine flow, which means the drug may leave their system more quickly.

How long does Ambien remain in the saliva?

  • After 15 minutes of taking Ambien, it is detectable for eight hours.
  • The detection window in saliva tests is relatively small.
  • A saliva test not performed within a day of taking Ambien may not be able to detect the drug's presence.

How long does Ambien remain in the hair?

  • Ambien can be detected in hair tests for up to 90 days following the last dose. 

Studies Related To Ambien Traces In The Body

  • Lewis studied how long Ambien is detectable in urine in 2007 and found that a metabolite was still detectable 72 hours after the last use.
  • Though Ambien has relatively poor absorption into growing hair, a study by Villain detected it in hair up to 5 weeks after taking the drug. 
  • Windows of detection of Ambien in urine and hair: application to two drug-facilitated sexual assaults.

Possible Side Effects Of Ambien

You should be careful with the side effects that might affect your body. When you suffer from side effects, you should get the necessary help from the doctor. 

Common Side Effects

Severe Side Effects

Sleepiness or drowsiness



Slowed or compromised breathing


Memory problems.

Unusual behavior.

Loss of consciousness.


Inability to Concentrate.

The effects mentioned above are not a complete list. Talk to your doctor if you suffer from any of the side effects not mentioned above.

Precautions Of Ambien

Taking preventive measures before you consume Ambien is necessary. This will help you not get affected by the side effects of the medicine. Inform your doctor about all the medicinal history you have been through.

Inform your doctor if you have suffered from the following:

  • Mental illness
  • Suicidal thoughts
  • Depression
  • Lung disease
  • Breathing issues
  • Kidney or liver issues.
  1. Do not consume alcohol when you are on Ambien medication
  2. Do not consume if you are pregnant
  3. Do not take the medicine while you are breastfeeding. The drug may enter the milk.

Ambien Addiction and Treatment

The FDA-approved label for Ambien states that persons with a history of substance addiction or substance use disorders are more likely to experience issues with Ambien misuse. Although addiction to Ambien is extremely rare, it is more often part of a larger pattern of drug abuse and addiction.

Signs of Addiction and Abuse      

  • Hallucinations.
  • Dizziness.
  • Nausea.
  • Unexpected behavior changes.
  • Irritability.
  • Sleepwalking and sleep driving.
  • Depression.
  • Suicidal ideation.

There are numerous approaches to treating Ambien addiction because addiction treatment is a complex and diversified field.

  • Rehab facilities offer therapy in friendly, calm, safe, and private settings that promote maximum healing and recovery.
  • Ambien detox: The aim of detoxification (detox) is to clear the system of drugs of Abuse, such as Ambien. It helps to combat the pressures of dependence and assure sobriety before moving on to other treatment phases. 
  • Behavioral therapy: It includes Cognitive-behavioural therapy, motivational interventions, contingency management, and other types of behavioral therapy. The objectives would be finding means to stop using, starting a recovery time, and preventing future relapse.
  • Sleep hygiene training: Sleep issues may persist during recovery because insufficient sleep drives Ambien use and addiction.

Bottom Line From Practical Anxiety Solutions

Ambien is a non-benzodiazepine drug used for treating insomnia in adults. How long Ambien stays in the system depends on age, weight, medications, underlying medical conditions, frequency of use and dosage, and kidney and liver function.

Since Ambien is a controlled substance, it has the potential for Abuse. Therefore, take this drug only after consulting a doctor.