By Irfana Parveen

B.Sc (Psychiatry Ward)

09 December 2021
Medically reviewed by
Sumayya Salam
Pharm D
Metizolam vs Etizolam
Table of Contents

What Is Metizolam?

The Metizolam (Desmethyletizolam) is a synthetic depressant that produces the same effects as Etizolam. It belongs to the thienodiazepine chemical class, used by patients suffering from anxiety, disinhibition, sedation, muscle suppression, and muscle relaxation. Metizolam has half power and has a 60 percent longer half-life than Etizolam(L.M. and Auwärter, V., 2016).

What Is Etizolam?

Etizolam, also known as Etilaam, Etizest, Depas, and many more, is a novel depressant substance. It also belongs to the thienodiazepine chemical class and treats anxiety, sedation, muscle relaxation, disinhibition, and euphoria. Etizolam is commonly not prescribed and is sold as a research chemical online. 

Etizolam is also used as a substitute for Xanax and Valium.(Furukawa, M. and Kurihara, K., 2008)Interactions

Many drugs are safe on their own and can become dangerous only when combined with other medications in some situations. Certain combinations may be safe in low doses but still increase the risk of side effects and must be taken cautiously. 

You can order Etizolam online  from a trustworthy online pharmacy, the medicine should be taken only as prescribed by the doctor.

Types of Medicines To Avoid When Using Metizolam And Etizolam:

  • Avoid depressants such as butanol, opioids, methaqualone, and alcohol, resulting in unexpected loss of consciousness at high doses. There is an increased risk of vomiting during unconsciousness, leading to death from the resulting suffocation. 
  • Dissociatives and Stimulants must almost be avoided. Stimulants decrease the sedative effect of benzodiazepines, but once the effect is worn off, the impact of Metizolam and Etizolam may be significantly increased, which leads to disinhibition and other effects. It also can lead to dehydration when combined(Auwärter, V., 2016).

Both Metizolam and Etizolam are similar in their uses and can increase the effects which they cause. 



Threshold Dose: Less than 1 mg

Light Dose: 1 - 2 mg

Common Dose: 2 - 4 mg

Strong Dose: 4 - 6 mg

Heavy Dose: 6 mg +

Duration: Total of 5-8 hours, Onset of 30-90 minutes, and after effects 10-30 hours. 


Threshold: 0.2 mg

Light: 0.5 - 1 mg

Common: 1 - 2 mg

Strong: 2 - 5 mg

Heavy: 5 mg +

Duration: Total of 5-7 hours, Onset of 15-30 minutes, and after effects 6-24 hours. 

Side Effects

Overdose or combining these medicines can increase the effects caused by the drugs and, in some cases, can be fatal. Consult your doctor if you notice any symptoms of these side effects.


  • Motor control loss
  • Respiratory depression
  • Dizziness
  • Vomiting
  • Loss of consciousness
  • Amnesia
  • Delusions of sobriety


  • Sedation
  • Motor control loss
  • Respiratory depression
  • Amnesia
  • Compulsive redosing
  • Sleepiness
  • Irritability
  • Temporary erectile dysfunction

Both these drugs have almost similar side effects. Patients using either of these two drugs must monitor their dosage and consult a doctor if anything seems worrisome. 

(Note: Both Metizolam and Etizolam can be highly addictive, use with caution). 

Study: Metizolam vs Etizolam

A study conducted at Collemaggio hospital in Italy researched the use of Etizolam to treat general anxiety. A double-blind study compared the effect of placebo versus Etizolam. 

A total of 36 patients were diagnosed who suffered from general anxiety disorder and were assessed for the tolerability of two unitary doses of Etizolam. After a week on placebo, the patients were randomly assigned to receive one tablet twice daily of Etizolam or placebo for five weeks. Ten patients were withdrawn before the study ended due to inadequate response. Analysis from the remaining 26 patients showed that Etizolam was better tolerated with few side effects and produced significant improvement in anxiety and depression than those who were on placebo.


Metizolam and Etizolam are not FDA-approved and are available online for purchase. Etizolam is mainly used for research purposes and is rarely used for treatment. We advise you to research these medicines individually or consult a doctor if you are unsure. (Huppertz, L.M. and Auwärter, V., 2016).

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