Published on 09 December 2021

Metizolam Vs Etizolam: Similarities, And Differences

Etizolam metizolam-vs-etizolam
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Anxiety is a common issue that affects many people. It is a feeling of sudden fear and confusion which may cause stiffness in your muscles. The condition has many reasons, such as stressful situations and low-income family well-being.

Other than that, it can be caused mainly due to any underlying disease conditions. In the US, there are 6.1% million people affected by Anxiety.

Many drugs are safe and can become dangerous only when combined with other medications. Certain combinations of drugs may be safe in low doses but still increase the risk of side effects and must be taken cautiously.

To overcome Anxiety, drugs like Metizolam and Etizolam are used, which help produce a calming effect in your brain. Both drugs are similar; let us understand more about them in detail.

What Is Metizolam?

Metizolam is a synthetic depressant that produces the same effects as Etizolam. It belongs to the thieno diazepine drug class related to benzodiazepine drugs. You might get the medicine by its trade name called, Desmethyletizolam. Metizolam has half power and a 60 percent half-life than Etizolam.

What Is Etizolam?

Etizolam, also known as Etilaam, Etizest, Depas, and many more, is a novel depressant that belongs to the thieno-diazepine class and treats anxiety, sedation, muscle relaxation, disinhibition, and euphoria. Etizolam is commonly not prescribed and is sold as a research chemical online.

Etizolam is also used as a substitute for Xanax and Valium. You can order Etizolam from a trustworthy online pharmacy, and theanine should be taken only as the doctor prescribes.

How Does Metizolam Work?

Metizolam is a psychoactive drug with the synthetic potential to calm the depressing chemicals within the body. Both the drug's working states are similar in increasing the GABA messenger, which allows you to relieve Anxiety. It has a half-life of about 60% longer, and 50% is less potent than Etizolam.

How Does Etizolam Work?

It is a Central nervous system drug that usually produces depressant effects. It works on the brain by increasing GABA, a chemical messenger, and abnormally excessive brain cell activity. It helps to treat conditions like Anxiety, sedation, anticonvulsants, and muscle-relaxing agents.

Frequently asked questions

When used for extended periods, the drug's adverse reactions are confusion, Excessive sedation, sleeping, and depression.
It was introduced in 1983 and used for neurological conditions like anxiety and sleep disorders. It is marketed in Japan, Italy, and India; the Food and Drug Administration in the US does not approve it. It can be used only for research purposes.
Drugs like Etizolam belong to similar benzodiazepine groups and should not be used for over 12 weeks.


Dosage is the most crucial factor that helps to determine the drug's working. One should take the medication with the correct dosage, frequency, and duration according to age and condition because it helps achieve therapeutic effects for the patient. If you consume the wrong dosages, the total drugs lead to developing unwanted adverse reactions in the body. Always consult your doctor before taking the medication.

Metizolam Dose

  • Initial Dose: 1 - 2 mg
  • Continuation dose: 2 - 4 mg
  • Strong Dose: 4 - 6 mg
  • Maximum dosage: 6 mg +
  • Duration: Total of 5-8 hours, Onset of 30-90 minutes, and after effects 10-30 hours.

Etizolam Dose

  • Initial dose: 0.2 mg, 0.5mg, or 1 mg
  • Continuation dose: 2 mg
  • Strong Dose: 2 - 5 mg
  • Maximum Dose: 5 mg +
  • Duration: Total of 5-7 hours, Onset of 15-30 minutes, and after effects 6-24 hours.

Possible Side Effects

Side effects can be caused to anyone after consumption of the medicine. The severity of such effects can differ for various individuals. Overdosing or combining these medicines with other drugs can increase the effects. In some cases, it can be fatal. Consult your doctor if you notice any side effects.



Respiratory depression





Slurred speech

Loss of consciousness




Delusions of sobriety

Temporary erectile dysfunction

Both these drugs have almost similar side effects. Patients using either of these two drugs must monitor their dosage and consult a doctor if anything seems worrisome. Both drugs can potentially get highly addictive, so use them with caution).

What Is Drug Withdrawal?

When a person consumes a drug for several days and suddenly stops the medication, it leads to withdrawal symptoms; it is known as a sudden quitting, cutting back the drugs. This leads to physical and mental dependence on the drug.

Metizolam Vs. Etizolam Withdrawal Effects

Metizolam and Etizolam are similar drugs that belong to the benzodiazepines group. Usually, benzodiazepines group drugs develop addictiveness. Therefore, Etizolam shows more potential use for dependence on others when comparing both drugs.

When you use large doses, it leads to life-threatening conditions. If you suddenly stop the drugs, it will lead to an increase in the risk of seizures. Some of the drugs' additional symptoms include insomnia, dysphoria, and tremors.

How Long Withdrawal Symptoms Last?

Withdrawal symptoms begin 28 to 48 hours after the last usage of the drug and last up to a few days to several months, depending upon the dosage. The drug users will report up to days to months of withdrawal symptoms.

Some of the symptoms you might get affected with are Disturbance in mood, Irritability, Tension, and Other symptoms like Anxiety, Panic attacks, Sleep disturbance, etc. are some of the additional symptoms one could suffer from.

Warnings Of Metizolam And Etizolam

Both drugs are similar and are used to treat similar conditions. Therefore precautions are identical; before starting the medication, be aware of the drug warnings, Speak with your healthcare provider, and inform them about your health conditions and drug history.

It should not be used with patients with increased eye pressure, coma, sleep disorder, lung disease, and hypersensitivity.
Moreover, drugs like Metizolam and etizolam belong to the anxiety agent and may develop addiction syndrome. So be aware of their use in a limited dosage with the help of your doctor.

During Pregnancy: Pregnant women or the person who is about to get pregnant should get advice from their doctor because this drug may cause harm to their fetuses. So avoid taking it during pregnancy.

Breastfeeding: The drug may pass into the breast milk and affect your newborn baby, so avoid taking it during breastfeeding or consult your doctor.

Drug Interactions of Metizolam And Etizolam

Metizolam and Etizolam are similar in their uses and can increase the effects they cause. People should not consume interactive medications together. This will create a lot of problems if two interactive drugs are consumed.

  • Avoid depressants such as butanol, opioids, methaqualone, and alcohol, resulting in unexpected loss of consciousness at high doses. There is an increased risk of vomiting during unconsciousness, leading to death from the resulting suffocation.
  • Dissociatives and Stimulants must almost be avoided. Stimulants decrease the sedative effect of benzodiazepines, but once the product is off, the impact of Metizolam and Etizolam may be significantly increased, which leads to disinhibition and other products. It also can lead to dehydration when combined.

Bottom Line From Practical Anxiety Solutions

To overcome anxiety-related conditions, drugs such as Metizolam and Etizolam are used. Both drugs belong to the group of Benzos. It is not marketed in the US but only through online pharmacies. If you wish to buy the pills, get the medicines from a genuine online pharmacy.

Although both drugs effectively treat Anxiety, sedation, and muscle relaxants, before administering the medication, know the caution measures to avoid adverse drug reactions.

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