By Irfana
B.Sc (Psychiatry Ward)
06 December 2021 -
Medically reviewed by
D. Pharm
Paxil For Premature Ejaculation
Table of Contents

Paxil (generic name paroxetine) is a selective serotonin reuptake inhibitor (SSRI) for treating a variety of mood disorders. Paxil is occasionally recommended As Paxil For Premature Ejaculation in addition to treating mood problems. (Pryor, J.L., Althof, S.E., Steidle, C., Rosen, R.C., Hellstrom, W.J., Shabsigh, R., Miloslavsky, M., Kell, S. and Dapoxetine Study Group, 2006)

Study On The Use Of Paxil For Premature Ejaculation:

The Australian Centre conducted this study for Sexual Health, St. Luke's Hospital, Sydney, to determine the efficiency of chronic and 'on demand' paroxetine hydrochloride administration in treating premature ejaculation (PE).

Ninety-four average men, ages 18 to 61 (mean 39), were treated with oral paroxetine as Paxil for premature ejaculation hydrochloride, a selective serotonin reuptake inhibitor, for premature ejaculation. All of the males were married or in a committed relationship. Sixty-four out of ninety-four males (Group A) were given paroxetine hydrochloride 20 mg once daily as an initial treatment. After four weeks, those men who improved their ejaculatory control were given 'on-demand paroxetine hydrochloride (20 mg) three to four hours before their intended intercourse. The remaining 33 of the 94 males (Group B) were given 20 mg of 'on-demand paroxetine hydrochloride 3-4 hours before their intended intercourse.

In 205 intercourses with a frequency of 0.4 intercourses per week, the mean pre-treatment ejaculatory latency time (ELT) of both groups A and B was 0.4 min (range 0-1 min). The mean ELT in group A was 4.5 minutes in 761 intercourses at a frequency of 2.4 intercourses per week following four weeks of daily Paxil medication. Fifty-three of the sixty-one men in group A thought their ejaculatory control had improved; therefore, they were given 'on-demand paroxetine, which helped them achieve an ELT of 3.9 minutes (range 0-10) in 608 intercourses with a frequency of 2.6 intercourses each week.

After another four weeks of treatment, 36 men in this group of 53 felt they had maintained improved ejaculatory control, with an average ELT of 5.5 minutes (range 2-20 minutes). With an average ELT of 0.7 minutes, the remaining 17 men experienced a relapse of poor ejaculatory control (range 0-2 min). After a mean of 4.5 weeks of therapy, the mean ELT in group B with initial 'on-demand paroxetine was 1.5 minutes (range 0-5 minutes) in 298 intercourses at a frequency of 2.2 intercourses per week. Anejaculation was reported in 5 out of 61 males using daily paroxetine, as was suppressed orgasm in 3 out of 61 men and lower libido in 3 out of 61 men. There were no reports of erectile problems, and 'on demand' paroxetine was not linked to any side effects.

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When administered on a chronic, 'on-demand basis following chronic treatment, or an initial 'on demand' basis, paroxetine(Paxil For Premature Ejaculation) hydrochloride appears to be a favorable agent in the pharmacological treatment of premature ejaculation.(Kendirci, M., Salem, E. and Hellstrom, W.J., 2007)

How To Use Paxil For Premature Ejaculation:

A study of over 100 men with PE found that taking 20mg of Paxil three to four hours before sex, both daily and as-needed, resulted in a longer ejaculation latency time as Paxil for premature ejaculation

Other Drugs For Premature Ejaculation:

Escitalopram: Escitalopram is an antidepressant and anxiety medication. It works by assisting in the restoration of a natural substance (serotonin) equilibrium in the brain. Escitalopram belongs to the selective serotonin reuptake inhibitors class of medicines (SSRI). It may increase your energy and emotions of well-being while also reducing anxiousness resulting in a delayed orgasm.

Fluoxetine: The active element of Prozac, fluoxetine, has been shown to be effective in treating PE in studies. Prozac's efficacy as a treatment for premature ejaculation is thought to be linked to the relationship between serotonin levels and ejaculation.

Sertraline: Research has proven Sertraline to be both safe and effective for the use of premature ejaculation. It can be more effective if it is consumed alongside behavioral and psychological treatments.

Side Effects Of Paxil:

Paxil (paroxetine hydrochloride) is a selective serotonin reuptake inhibitor (SSRI). Here are some common side effects:

  • Difficulty in having an orgasm.
  • Impotence.
  • Nasal irritation.
  • Headaches.
  • Nausea,
  • Insomnia.


Premature ejaculation is nothing to be ashamed about; almost everyone has experienced it. Treating it requires your and your doctor's attention.

Don’t ignore the problem, we know it can be overwhelming to address it, but if done correctly, it can be dealt with(Mercado, M.G., Kimmer, S.L., Holman, J.R. and Wanserski, G.R., 2008).

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