29 August 2022
Medically reviewed by
Kajal Jain
M. Pharm
Tramadol For Anxiety
Table of Contents

Anxiety is the familiar feeling of extensive fear or worries for a particular reason. Nearly it affects more than 30./adults. The exact causes of Anxiety are unknown. But the resources say some full triggers will impact your mind and body. It will develop symptoms like a fast heartbeat, nervousness, tension, weak fullness, sweating, not concentrating on work, crying, etc.

There are some significant symptoms. Still, Anxiety is treatable with effective treatment like healthy living and behavioral and diversional therapy. It will help you to get rid of stress to some extent. 

Medications like Tramadol are effective in treating Anxiety because it is an analgesic that will keep your mind and body calm and relaxed. Let us see more about the drug.

What Is Tramadol?

Tramadol is a prescription opioid pain reliever used to treat moderate to extreme pain. It works via two molecular mechanisms in the brain, one of which causes an elevated mood while the other blocks the transmission of signals for nerve cells that carry painful stimuli (e.g., neurotransmitters).

First, the drug inhibits mu-opioid receptor activity. Second, it decreases serotonin and norepinephrine reuptake in neurons by binding to specific transporters associated with those neurotransmitters. 

What's The Drug Class Of Tramadol?

Tramadol and Tapentadol fall under an opioid analgesic that comes in a class of medications called narcotics. It changes the way our brains and nervous systems respond to pain by blocking specific receptors in these parts of your body that cause you to feel it more intensely than usual.

How Does Tramadol Help In Dealing With Anxiety?

An individual suffering from Anxiety is often seen to have an overwhelming feeling that can become generalized, but there's nothing to worry about; you'll do fine! Taking proper medication from a healthcare professional could be the right thing to do.

Many researchers have exhibited doctors' prescribed pill as Tramadol to treat Anxiety and depression with lesser side effects. We've provided general information about the medication to help you gather authentic information about Tramadol treating your Anxiety.

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What Is Tramadol Used For, And How Does It Works?

Tramadol is a painkiller that reduces the sensation of chronic and acute forms of pain from multiple sources. It's less addictive than other opioids, which makes it a practical option for those who suffer from painful conditions without being at risk of addiction or overdose risks associated with opiate-based drugs like morphine.

Chronic pain can cause an individual to think about it and initially lead to Anxiety and anxiousness. Thus the consumption of the drug lowers the effect of depression.

The mechanism involves activating specific receptors within the central nervous system to reduce signals from neurons related to physical distress.

It is responsible for infusing calming and relaxing feelings by blocking those discomforting sensations traveling from nerves to the brain.

Drugs like Tramadol cause gastrointestinal problems like nausea and vomiting. Meanwhile, experts are not sure why this is happening; they say a factor is chemoreceptors are the trigger zone present in the brain, which usually causes a vomiting sensation.
Tramadol is given in the route of intravenous injection; it should provide slowly over two or three minutes to avoid sudden unwanted side effects of the drug.
It belongs to the type of Narcotic medicine called opioids to treat moderate to severe pain in patients.

Side Effects Of Tramadol

Tramadol has a weak affinity for the mu-opioid receptor, but its metabolites have stronger relationships. A Medication May Have Severe Side Effects If You Take It For A Long Time Or Consume Alcohol And Other Drugs. This may be why users find that Tramadol can produce desirable effects even though it isn't an opioid relationship.

Common Side Effects Severe Side Effects
Drowsiness Addiction
Stomach upset Irregular breathing
Head pain Withdrawal signs
Inflammation Suicidal thoughts
Weakness Seizures

Tramadol Dosages For Anxiety

The general dosage for adults is 50-100 milligrams three times a day to manage acute pain. The maximum dosage for adults should not exceed 400 mg per day.

You can swallow it with water, but some might find it bitter, so you could also chew on the film coating that protects your tongue from taste bud exposure until powder coats are released into saliva stimulation.

According to the National Institutes of Health, older adults or people with hepatic impairment should have a lower dosage. The doctors recommend this because it does not cause more damage to the liver, and also, for children, there are different medical norms in other countries.

In the UK, children under 12 are not prescribed Tramadol for pain. However, in Germany, it is given to infants below 1 year of age when needed, and in the USA, the age bar is below 16 years.

If you are taking this medicine in liquid format, the drops/mg chart table below.





1 drop

2.5 Mg

5 drops

12.5 Mg

10 drops

25 Mg

15 drops

37.5 Mg

20 drops

50 Mg

25 drops

62.5 Mg

30 drops

75 Mg

35 drops

87.5 Mg

40 drops

 100 Mg

A case study is shown on patients with moderate to severe postoperative pain. Intravenous Tramadol 50 to 150mg was equivalent in analgesic efficacy to morphine 5 to 15mg in patients with mild pain following surgery.

Tramadol Precautions

People with respiratory conditions such as asthma and emphysema should also avoid opioids. Additionally, avoiding adulterated beverages like alcohol is essential because Tramadol may increase the effects of any other drug you take at once, which could result in a high feeling without intending to.

  • Do not consume Tramadol from street vendors, as it may cause damage to your system.
  • Do not consume during pregnancy or breastfeeding, as it may affect the newborn health.
  • People on other anti-depressants should avoid Tramadol.
  • Do not drive a vehicle or operate heavy machinery, as it may result in an accident.

Risk May Be Higher If You Have Ever Had:

  • A head injury, epilepsy, or other seizure disorder
  • Drug or alcohol addiction
  • A metabolic disorder.

Tramadol Overdose

A regular tramadol dosage can cause serious, even life-threatening, side effects. When an individual who has developed a tolerance to Tramadol takes more than expected, they may experience overdose symptoms.

An overdose could be harmful many times and can cause:

  • Neurological toxicity
  • Respiratory failure
  • Serotonin syndrome
  • Mild cardiovascular disruption

Overdosed Symptoms Of The Drug Include

  • Contracted pupils.
  • Extreme drowsiness.
  • Slowed breathing.
  • Slowed heartbeat.
  • Weak muscles.
  • Clamminess.
  • Loss of consciousness.


While Tramadol is typically prescribed for short-term use, it can create feelings of euphoria and decreased Anxiety. Because people feel so good when they take the drug, many users will continue to seek the positive effects by taking more than their prescriptions allow.

As users increase their dosage of Tramadol, they become physiologically dependent on the drug. In other words, if a user were to stop taking it suddenly or reduce their dose significantly, then withdrawal symptoms could occur.

There's a case study on a 37-year-old male suffering from a sprain injury in the leg who was prescribed to take Tramadol, which relieved his pain. Later became comfortable with the medicines. He started to take Tramadol after every injury and increased dosages, and suddenly after stopping, he began to face headaches, sneezing, and disturbed sleep.


Patients physiologically dependent on Tramadol can experience withdrawal symptoms similar to those reported with other opioids.

Some symptoms of withdrawal include:

  • Nausea.
  • Anxiety.
  • Irritability.
  • Insomnia.
  • Mood swings.
  • Paranoia/hallucinations.
  • Tremors.

The severity of these symptoms depends on the level of tolerance developed and how long it has been since a person's last dose, and dosage was taken.

How Tramadol Addiction Changes Your Life?

Tramadol is typically abused by those with a history of substance abuse and many who have been prescribed it for pain control.

Many Tramadol abusers report strained relationships with family and troubles at work/school due to their need for the drug. Many also experience financial trouble from clinic visits or having to purchase illegally.

A mother's use of Tramadol during her pregnancy may result in congenital disabilities due to their newborn being physiologically addicted when they are born.

Tramadol Usage Warnings:

Addiction and misuse:

Tramadol misuse includes taking it in more significant dosages, more frequently, without a prescription for a more extended period than congenital disabilities can develop dependency.

Slowed or stopped breathing: 

This drug has the effect of slowing breathing. If it is not treated correctly, it can lead to death. So use the dosage recommended by your doctor.

Children warning:

The drug can lead to process in children's bodies more quickly, leading to stopping breathing or death. So the drug should not be given to children younger than 12.

Interaction with other drugs:

Taking the medication with different groups of medicines can cause severe side effects, the possibility of attack seizure, and low levels of serotonin syndrome. therefore avoid taking it with

  •  Amiodarone
  • Quinidine
  • Erythromycin
  • Ketoconazole
  • Ritonavir

Allergy warning:

Suppose you have an allergic reaction to the use of the drugs, like swelling of your face lips and itching on the skin. Call your doctor immediately and stop using this drug.

Bottom Line From Practical Anxiety Solutions

Tramadol is benzo that effectively treats acute, chronic pain. Benzos are used as pain medicines for more extended effects on nerves. Thus, it is used for other purposes too. While purchasing Tramadol, be ready with your prescription for the ordering process.

Consume the drug with a recommended dosage, or else it leads to habit-forming of the drug and increases the side effects of the drug. Talk to your doctor about your past health history before starting the medication.

  • Yang, Bo Ram, et al. "Characterizing tramadol users with potentially inappropriate co-medications: A latent class analysis among older adults." PloS one 16.2 (2021): e0246426. Obtain On 01/11/2022
  • Caspani, Ombretta, et al. "Tramadol reduces anxiety-related and depression-associated behaviors presumably induced by pain in the chronic constriction injury model of neuropathic pain in rats." Pharmacology Biochemistry and Behavior 124 (2014): 290-296. Obtain On 01/11/2022
  • Burak, A. Y. A. N., and Güniz Meyanci Köksal. "Effects of Oral Alprazolam and Oral Tramadol on Anxiety and Analgesia in Patients Undergoing Breast Cancer Surgery." (2021). DOI: Obtain On 01/11/2022
  • Antiorio, Ana Tada Fonseca Brasil, et al. "Assessment of general activity and anxiety-like behavior in mice following tramadol and meloxicam administration for managing immediate post-operative pain." Biological Models Research and Technology 2.1 (2022): 0-0. Obtain On 01/11/2022
  • Tulaci, K.G., Arslan, E., Tulaci, R.G. et al. Effect of prilocaine and its combination with tramadol on anxiety and pain during nasal packing removal. Eur Arch Otorhinolaryngol 277, 1385–1390 (2020). Obtain On 01/11/2022
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