19 August 2019 - 5 min read
Medically reviewed by
Know the Effects of Tramadol in Reducing Anxiety.
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How Does Tramadol Helps In Dealing With Anxiety?

An individual suffering from anxiety is often seen to have an overwhelming feeling that can become generalized, but there’s nothing to worry about; you’ll do fine! Taking proper medication from a healthcare professional could be a rightful thing to do.

Many researchers have exhibited doctors’ prescribed pills as Tramadol for pain, which also has a relaxing effect and works to reduce anxiety and depression with lesser side effects. We’ve provided general information about the medication to help you gather authentic information about Tramadol in treating your anxiety.

What Is Tramadol?

Tramadol is a prescription opioid pain reliever used to treat moderate to extreme pain. It works via two molecular mechanisms in the brain, one of which causes an elevated mood while the other blocks transmission of signals for nerve cells that carry painful stimuli (e.g., neurotransmitters).

First, the drug inhibits mu-opioid receptor activity. Second, it decreases serotonin and norepinephrine reuptake in neurons by binding to specific transporters associated with those neurotransmitters.

What Is Tramadol Used For, And How It Works?

Tramadol is a painkiller that reduces the sensation of chronic and acute forms of pain from multiple sources. It’s less addictive than other opioids, which makes it a practical option for those who suffer from painful conditions without being at risk of addiction or overdose risks associated with opiate-based drugs like morphine.

The regular pain can cause an individual to think about it and initially lead to anxiety and anxiousness, thus the consumption of the drug lowers the effect of depression.

The mechanism involves activating certain receptors within the central nervous system to reduce signals sent by neurons related to physical distress.

It is responsible for infusing calming and relaxing feelings by blocking those discomforting sensations traveling from nerves to the brain.

What’s The Drug Class Of Tramadol?

Tramadol and Tapentadol both fall under an opioid analgesic that comes in a class of medications called narcotics. It changes the way our brains and nervous systems respond to pain by blocking certain receptors in these parts of your body that cause you to feel it more intensely than usual.

Side Effects Of Tramadol

Tramadol has a weak affinity for the mu-opioid receptor, but its metabolites have stronger affinities. This may be why users find that Tramadol can produce desirable effects even though it isn’t an opioid itself.

Some common side effects include:

  • Drowsiness
  • Nausea
  • Stomach upset
  • Head pain
  • Skin rashes and itching
  • Inflammation
  • Anxiety
  • Weakness
  • Sweating
  • Low appetite

A Medication May Have Severe Side Effects If You Take It For A Long Time Or Consume Alcohol And Other Drugs. Severe Effects Include:

  • Addiction
  • Abuse
  • Irregular breathing
  • Lung disorder
  • Sweat and shivers
  • Withdrawal signs
  • Seizures
  • Sleep apnea
  • Suicidal thoughts
  • Hypertension
  • Brain tumor
  • Fluctuating pulse rate


The general dosage for adults is 50-100 milligrams three times a day to manage acute pain. The maximum dosage for adults should not exceed 400 mg per day.

You can swallow it with water, but some might find it bitter in taste so you could also chew on the film coating that protects your tongue from taste bud exposure until powder coats are released into saliva stimulation.

According to the National Institutes of Health, older adults or people with hepatic impairment should have a lower dosage. The doctors recommend that this is because it does not cause more damage to the liver and also for children, there are different medical norms in different countries.

In the UK, children under 12 are not prescribed Tramadol for any pain. However, in Germany, it is given to infants below 1 year of age when needed and in the USA the age bar is below 16 years.

A case study is shown on the patients with moderate to severe postoperative pain and Intravenous Tramadol 50 to 150mg was equivalent in analgesic efficacy to morphine 5 to 15mg in patients with moderate pain following surgery. The study was done by Lee, C.R., McTavish, D. & Sorkin, and E.M. Tramadol. (https://link.springer.com/article/10.2165/00003495-199346020-00008)


People with respiratory conditions such as asthma and emphysema should also stay away from opioids. Additionally, it is important to avoid drinking adulterated beverages like alcohol because Tramadol may increase the effects of any other drug you take at once which could result in a high feeling without intending to.

  • Do not consume Tramadol from street vendors, as it may cause damage to your system.
  • Do not consume during pregnancy or breastfeeding as it may affect the new-born health.
  • People on other anti-depressants should avoid Tramadol.
  • Do not drive a vehicle or operate heavy machinery, as it may result in an accident.

Tramadol Overdose

When an individual who has developed a tolerance to Tramadol takes more than normal, they may experience symptoms of overdose.

An overdose could be harmful many times and can cause:

  • Neurological toxicity
  • Respiratory failure
  • Serotonin syndrome
  • Mild cardiovascular disruption

Overdosed Symptoms Of The Drug Includes

  • Seizures
  • Coma
  • Hypertension
  • Tachycardia
  • Lethargy
  • Nausea
  • Agitation


While Tramadol is typically prescribed for short-term use, it can create feelings of euphoria and decreased anxiety. Because people feel so good when they take the drug many users will continue to seek the positive effects by taking more than their prescriptions allow.

As users increase their dosage of Tramadol, they become physiologically dependent on the drug. In other words, if a user were to stop taking it suddenly or reduce their dose significantly then withdrawal symptoms can occur.

There’s a case study on a 37-year-old male who was suffering from a sprain injury in the leg and prescribed to take Tramadol which resulted in relief to his pain. Later become comfortable with the medicines he himself started to take Tramadol after every injury and increased dosages and suddenly after stopping he began to face headaches, sneezing and disturbed sleep. To learn more read the study was done by Prakash J, Saini R. Tramadol Dependence: A Case Report. Med J Armed Forces India. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920898/)


Patients who are physiologically dependent on Tramadol can experience withdrawal symptoms similar to those reported with other opioids.

Some symptoms of withdrawal include:

  • Nausea.
  • Anxiety.
  • Irritability.
  • Insomnia.
  • Mood swings.
  • Paranoia/hallucinations.
  • Tremors.

The severity of these symptoms depends on the level of tolerance developed, as well as how long it has been since a person’s last dose and dosage taken.

How Tramadol Addiction Changes Your Life?

Tramadol is typically abused by those with a history of substance abuse and many who have been prescribed it for pain control.

Many Tramadol abusers report strained relationships with family, troubles at work/school due to their need for the drug. Many also experience financial trouble from clinic visits or having to purchase illegally.

A mother’s use of Tramadol during her pregnancy may result in birth defects due to their newborn being physiologically addicted when they are born.

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