SUMAYYA
26 September 2022
Medically reviewed by
Kajal Jain
M. Pharm
AMBIEN SUBLINGUAL
Table of Contents

Sleeping disorders are widely spreading among all groups of people. There are some natural ways to treat your sleep issues, but after several tries, If you don't get rid of it. You are mainly suffering from an insomnia condition; hence seek medical attention immediately.

Zolpidem (Ambien) is a sedative-hypnotic medicine. It treats insomnia in adults who have sleep difficulties.

Zolpidem sublingual tablets are federally controlled substances (C-IV) as they can be abused or lead to dependence. For awakening in the middle of the night zolpidem sublingual route is specifically designed to treat this sleep disorder. 

Let us understand in detail,

What Is Zolpidem?

Zolpidem (Ambien) is a sedative-hypnotic medicine. It treats insomnia in adults who have sleep difficulties.
Zolpidem sublingual tablets are federally controlled substances (C-IV) as they can be abused or lead to dependence.

Zolpidem Sublingual Tablets

The US Food and Drug Administration approved Zolpidem Sublingual Tablets in November 2011, for insomnia characterised by difficulty returning to sleep after middle-of-the-night (MOTN) awakening, with at least 4 hours left before waking up. 
Brand names of zolpidem sublingual tablets include Edluar (sublingual tablet) and Intermezzo (sublingual tablet).

The rationale for developing this medication may help people fall asleep quickly and is effective for treating occasional insomnia.

A study on healthy volunteers comparing the first-night effect and post-nap sleep in terms of sleep onset latencies revealed that it is very effective in causing sleep initiation disruptions.

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Uses Of Ambien Sublingual Tablets

For short treatment of insomnia, characterised by difficulties with sleep initiation

Dosing Information

Intermezzo

  • Recommended dose:1.75 mg for women and 3.5 mg for men.
  • Take one per night as needed if a middle-of-the-night awakening is followed by difficulty returning to sleep.
  • Only take the sublingual tablets if you have at least 4 hours of bedtime left. 

      2. Edular

  • Available doses: 5 mg and 10 mg
  • The recommended initial dose is 5 mg for women and either 5 or 10 mg for men, once per night before bedtime, 7-8 hours before the planned time of awakening.
  • The maximum dose of Edular should not exceed 10 mg.

Note: The safety and efficacy of zolpidem tartrate sublingual tablets have not been studied in the paediatric population. There are also no adequate studies of the medication in pregnant women.

Studies Related To Zolpidem Sublingual Use In Insomnia

  • A study by Staner indicates that a sublingual formulation of 10 mg zolpidem could reduce the time to sleep initiation by 30% compared to an oral formulation. 
  • Five studies reported an increase in slow wave sleep, whereas 12 other studies found an unchanged effect.
  • Compared to baseline readings, individuals taking Zolpidem Sublingual Tablets 3.5 mg exhibited a 30-min reduction in Latency of Sleep Onset after the middle- of- the- night awakenings (LSOMOTN) and an approximately 18-min faster sleep onset than placebo. 

Side Effects Of Ambien Sublingual Tablets

Common Side Effects

  • Headache
  • Nausea and vomiting
  • Fatigue
  • Serious side effects
  • Allergic reactions- swelling of your face, lips, and throat that may cause difficulty breathing or swallowing
  • Complex sleep behaviors- sleepwalking, sleep eating, and sleep driving
  • Confusion, agitation, hallucinations,
  • Depression
  • Suicidal thoughts
  • Memory loss
  • Anxiety

How To Take Ambien Sublingual Tablets?

  • Place the tablet under your tongue, allow it to break apart completely, and then swallow.
  • Do not swallow the zolpidem sublingual tablets as whole.
  • Only take one sublingual tablet per night if needed.
  • Only consume zolpidem tartrate sublingual tablets if at least four hours remain before bedtime.

What Is The Important Information I Should Know About Ambien Sublingual Tablets?

  • Follow the directions on the zolpidem tartrate sublingual pills exactly.
  • If you consumed alcohol that evening or before bed, avoid taking zolpidem tartrate sublingual pills.
  • Do not swallow the sublingual tablet as a whole.
  • Do not take zolpidem tartrate sublingual tablets with or right after a meal. Zolpidem tartrate sublingual tablets on an empty stomach may help you fall asleep faster.
  • Contact your doctor if your insomnia worsens or does not get better within 7 to 10 days.
  • Seek immediate medical attention if you consume too many zolpidem tartrate sublingual pills or if you overdose.

How Should I Store Zolpidem Tartrate Sublingual Tablets?

  • Store zolpidem tartrate sublingual tablets between 68 -77 degrees Fahrenheit. Keep the medication away from moisture.
  • Keep all medications, including zolpidem tartrate sublingual tablets, away from children.

Conclusion

The zolpidem sublingual tablet fills a crucial need because middle-of-the-night waking is a frequent core symptom of primary insomnia.

Make sure you follow the instructions when you take the medication. Call your healthcare provider if you have any side effects that worry you while using the sublingual tablets.

  • Staner, L., Eriksson, M., Cornette, F., Santoro, F., Muscat, N., Luthinger, R., & Roth, T. (2009). Sublingual zolpidem is more effective than oral zolpidem in initiating early onset of sleep in the post-nap model of transient insomnia: A polysomnographic study. Sleep Medicine, 10(6), 616-620. From https://doi.org/10.1016/j.sleep.2008.06.008 Obtain on 26/09/2022
  • Staner, Luc, Philippe Danjou, and Remy Luthringer. "A new sublingual formulation of zolpidem for the treatment of sleep-onset insomnia." Expert Review of Neurotherapeutics 12.2 (2012): 141-153. From   https://doi.org/10.1586/ern.11.197 Obtain on 26/09/2022
  • Edinoff, A. N., Wu, N., Ghaffar, Y. T., Prejean, R., Gremillion, R., Cogburn, M., Chami, A. A., Kaye, A. M., & Kaye, A. D. (2021). Zolpidem: Efficacy and Side Effects for Insomnia. Health Psychology Research, 9(1). From https://doi.org/10.52965/001c.24927 Obtain on 26/09/2022
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