When you experience an orgasm before or within a minute of starting intercourse, this is known as premature ejaculation (PE). Although there is no specific time for a guy to ejaculate during sex, if you ejaculate and lose your erection thus quickly, you and your partner may feel rushed.
Premature ejaculation can be influenced by both psychological and biological reasons. Premature ejaculation is a common and treatable problem, although many men are reluctant to talk about it. Medications, counseling, and sexual techniques that postpone ejaculation (or a mix of these) can all help you and your partner have better sex.Â
Early methods for treating PE were behavioral treatment, which included the start-stop and squeeze procedures. Recent investigations have documented the therapeutic effects of topical anesthetics, selective serotonin reuptake inhibitors, and tricyclic antidepressants. Clomipramine has been found to increase ejaculatory latency in men with PE. Let us see in detail how Clomipramine works for Premature Ejaculation.
Premature ejaculation was revolutionized when selective serotonin reuptake inhibitors (SSRIs) were introduced. In 1994, the first research on SSRIs in men with premature ejaculation found that paroxetine had a delaying effect (Paxil). Since then, SSRIs have been studied extensively for their ability to delay ejaculation. For premature ejaculation, SSRIs and the tricyclic antidepressant clomipramine (Anafranil) have been the drugs of choice.
Despite considerable differences in design and drug dosing, Clomipramine, Fluoxetine (Prozac), Paroxetine, and Sertraline (Zoloft) significantly delay ejaculation compared to placebo, according to a meta-analysis of 35 treatment studies with serotonergic antidepressants conducted between 1943 and 2003.
Clomipramine is a tricyclic antidepressant used to treat obsessive-compulsive disorder. It is one of the more sedating tricyclic antidepressants used as a hydrochloride salt for treating phobias, OCD, and depression.
It functions as a trypanothione-disulfide reductase inhibitor, serotonergic drug, serotonin antagonist, antidepressant, and anti-coronavirus agent. It is similar to imipramine in terms of function.
Clomipramine is a tricyclic antidepressant with anti-obsessional effects. Clomipramine, like other tricyclics, prevents norepinephrine and serotonin from entering central nerve terminals, presumably by impeding the membrane pump of neurons.
Thus, clomipramine raises the level of transmitter monoamines at receptor locations. By altering serotonergic neurotransmission, clomipramine affects depression and compulsive and obsessive behavior.Â
It appears that clomipramine has a modest sedative effect that could be useful in reducing the anxiety that frequently goes along with depression. The anticholinergic properties of clomipramine, like those of other tricyclic drugs, have some negative consequences.
Clomipramine demonstrates weak antihistamine and anti-serotonin actions. It lowers the threshold for convulsions and improves the effects of norepinephrine and other drugs on the central nervous system. The ability of clomipramine to prevent serotonin reuptake is significant.
Tricyclic antidepressants and SSRIs likely cause delayed ejaculation by inhibiting some descending pathways connected to the ejaculatory reflex.
Several studies have demonstrated that clomipramine, a tricyclic antidepressant, can effectively manage PE at various doses. Clomipramine may work by inhibiting the ejaculatory reflex, reducing psychologic arousal, or exerting anxiolytic effects.Â
Clomipramine was tested to see if it increased ejaculation delay in males with premature ejaculation and controls. The study comprised eight patients with primary premature ejaculation, six with primary premature ejaculation and erectile dysfunction, and eight controls.Â
The study used a prospective, double-blind, placebo-controlled crossover design with two 3-week periods of Clomipramine and placebo. Individuals received either 25 mg of clomipramine or a placebo during the treatment period, 12 to 24 hours before the anticipated sexual activity.
In men with primary premature ejaculation, Clomipramine increased the latency to ejaculation during sexual activity (coitus or masturbation) from around 2 to 8 minutes. Controls and males with premature ejaculation and erectile dysfunction had no meaningful effects.Â
According to laboratory findings, Clomipramine improved the regulation of ejaculatory response in men with primary premature ejaculation. Clomipramine also boosted these men's happiness with their sex lives and relationships.
In all of the individuals, Clomipramine prevented nocturnal penile tumescence. To summarise, Clomipramine increases ejaculatory latency efficiently in men with primary premature ejaculation, while it is ineffective in males with premature ejaculation plus erectile dysfunction.
You cannot get Clomipramine over the counter as it is a prescription-based drug. You can buy Clomipramine online from a legit online pharmacy but ask for a doctor's advice first.Â
When patients receive drugs in doses that fit their unique needs for an adequate amount of time at the lowest possible cost, this is considered the rational use of medicines. An improper dose regimen can cause health issues, especially in children and people with chronic illnesses. Therefore, it is necessary for designing the desired dosing regimen to achieve the intended therapeutic efficacy and prevent side effects.
Men with premature ejaculation might initially be considered for treatment with Clomipramine 25 mg (or less) taken as needed 24 h before sexual intercourse. If this treatment is not successful, daily clomipramine with initially 10 mg and increasing to 30 mg may be required.
IELT(Intravaginal Ejaculatory Latency Time) Fold Increase
12.5-50 mg/day orÂ
12.5-50 mg on demand
Side effects of medications are undesired effects that occur after the administration of the drug. Pay attention to any unwanted effects and take note of any changes.
To ensure that you remember to inform your physician, pharmacist, or other healthcare providers of the changes, note them down.
Know what to do and when to tell your doctor if you have adverse effects.
New or worsening depression
These are necessary steps for preventing unusual events. Read all drug manuals and follow the instructions carefully. Call your doctor immediately if you note severe symptoms.
Before you take Clomipramine
Interactions can sometimes result in reactions causing harm to the patient. Before starting any new drug, check for potential interactions with existing medications or dietary supplements.
Premature Ejaculation is a sexual dysfunction affecting 30-40% of the male population. It is defined as any ejaculation that occurs between one and seven minutes (9-11). The primary symptom of PE is the inability to delay ejaculation for more than a minute after penetration.
Men with PE may be treated pharmaceutically using a variety of techniques. The lower risk, expense, and adverse effects related to clomipramine use are the main reasons for the choice of initial therapy as required. Clomipramine is effective, and its adverse effects are well tolerated. In addition to or in place of psychological treatment for PE, clomipramine is a safe treatment option.Â
WALDINGER, M. D. (2002). The Neurobiological Approach to Premature Ejaculation. Journal of Urology, 168(6), 2359â€“2367. https://doi.org/10.1016/s0022-5347(05)64146-8
Beaumont, G. (1977). Sexual side-effects of clomipramine (Anafranil). The Journal of International Medical Research, 5(1 Suppl), 37â€“44. https://europepmc.org/article/med/863089Â
Does Wellbutrin Cause Weight Loss Or Weight Gain?
Irfana Parveen 19 September 2021
Wellbutrin Vs Lexapro: Which Is Best For Anxiety?
Irfana Parveen 19 September 2021
Anxiety & Depression
Over The Counter Anxiety Medications: Any Option?
Irfana Parveen 19 September 2021