The Efficacy of Clomipramine in the Treatment of Premature Ejaculation

When you experience an orgasm before or within a minute of starting intercourse, this is known as premature ejaculation (PE). Although there is no specific time for a guy to ejaculate during sex, if you ejaculate and lose your erection thus quickly, you and your partner may feel rushed. 

Premature ejaculation can be influenced by both psychological and biological reasons. Premature ejaculation is a common and treatable problem, despite the fact that many men are reluctant to talk about it. Medications, counseling, and sexual techniques that postpone ejaculation (or a mix of these) can all help you and your partner have better sex.(Slob, A.K., 1999)

Antidepressants For The Treatment Of Premature Ejaculation

Premature ejaculation was revolutionized when selective serotonin reuptake inhibitors (SSRIs) were introduced. In 1994, the first research of SSRIs in men with premature ejaculation found that paroxetine had a delaying effect (Paxil). Since then, SSRIs have been studied extensively for their ability to delay ejaculation. For the treatment of premature ejaculation, SSRIs and the tricyclic antidepressant clomipramine (Anafranil) have been the drugs of choice.

Despite considerable differences in design and drug dosing, Clomipramine, fluoxetine (Prozac), paroxetine, and sertraline (Zoloft) significantly delay ejaculation when compared to placebo, according to a meta-analysis of 35 treatment studies with serotonergic antidepressants conducted between 1943 and 2003.(Segraves, K. and Maguire, E., 1993)

Scientific Study On Clomipramine For Premature Ejaculation

Clomipramine was tested to see if it increased ejaculation delay in males with premature ejaculation and controls. Eight patients with primary premature ejaculation, six with premature ejaculation plus erectile dysfunction, and eight controls were included in the study. 

The study used a prospective, double-blind, placebo-controlled crossover design with two 3-week periods of Clomipramine and placebo. During the treatment phase, individuals were given either 25 mg clomipramine or placebo as needed, 12 to 24 hours before the sexual activity was expected.

In men with primary premature ejaculation, Clomipramine increased the latency to ejaculation during sexual activity (coitus or masturbation) from around 2 to 8 minutes. Controls and males with premature ejaculation and erectile dysfunction had no meaningful effects. 

Clomipramine medication improved the regulation of ejaculatory response in men with primary premature ejaculation, according to laboratory findings. Clomipramine also boosted these men’s happiness with their sex lives and relationships. In all of the individuals, Clomipramine prevented nocturnal penile tumescence. To summarise, Clomipramine increases ejaculatory latency efficiently in men with primary premature ejaculation, while it is ineffective in males with premature ejaculation plus erectile dysfunction. (Goodman, R.E., 1980)

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