By Sudeshna Saha

Bachelor of Physiotherapy

12 December 2021
Medically reviewed by
Sumayya Salam
Pharm D
Table of Contents

Wellbutrin goes by the generic name, Bupropion. Wellbutrin Is not an SSRI

It is an antidepressant that includes tetracyclic agents that act by inhibiting both serotonin and norepinephrine in the body. Wellbutrin treats depression, narcolepsy, attention deficit hyperactivity disorder (ADHD), and Parkinson’s disease.  

It was approved on 30th December 1985 by the FDA. 

Wellbutrin belongs to a class of drugs called Norepinephrine and Dopamine Reuptake Inhibitors (NDRIs). Wellbutrin works by blocking the action of both norepinephrine transporters and dopamine transporters, unlike SSRIs, which blocks serotonin transport in neurons. Though both NDRIs and SSRIs can treat depression, their mechanism is different. 

Wellbutrin also blocks nicotine’s effect, making it useful in smoking cessation. Wellbutrin’s action is complex, and its neurological effects are not fully understood.

Focalin, Ritalin, and Wellbutrin are some NDRI medications approved in the US to treat ADHD and depression(Hasnain, M. and Pandurangi, A.K., 2008).

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How To Take Wellbutrin?

It would be best if you took Wellbutrin as prescribed by your doctor. Follow the directions on the prescribed label. Taking too much of this medicine can cause seizures. 

Do not crush, break or chew the extended-release tablet. You have to swallow it whole. Also, it is not advisable to intake Wellbutrin under the influence of alcohol. You can order Wellbutrin online  from a verified online pharmacy.

Your blood pressure should be monitored during and after the treatment of Wellbutrin. Unless you have seizures or any side effects, do not stop using the medicine. Please consult your doctor before discontinuing its use(Zimmerman, R.H., 2000).


Wellbutrin is taken orally at doses of 75 mg tablet, a 100 mg tablet, and 150 mg tablet for extended-release(XR). The 150 mg tablet is the most popular.

The 150 mg tablet dose can be taken as one tablet two times a day. We suggest you avoid exceeding 450 mg in a day. Follow the doctor’s instructions to prevent risks(Edin, H.M., 2006).

Side Effects

Some people may experience agitation, restlessness, and insomnia in the first few days of the treatment. You must call your doctor if you face:

  • Seizure
  • Confusion
  • Blurred vision
  • Irregular heartbeats
  • Dizziness
  • Muscle or joint pain
  • Dry mouth
  • Headache

Some psychological effects such as feelings of restlessness, delusions, or a sense of depersonalization may occur. The patients must be monitored for any worsening effects caused by the medicine. 

Things To Remember

Use this medication regularly to see its benefits. Do not stop the medication suddenly without consulting your doctor. Your dose may be gradually decreased if the doctor feels the need to. 

Wellbutrin requires about four or more weeks to show its benefits(Dal Negro, R.W., 2015).

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