NASRIN KAPADIA
By Nasrin Kapadia

B. A. Psychology

07 April 2022
Medically reviewed by
Sumayya Salam
Pharm D
Can I take Melatonin with Trazodone for sleep?
Table of Contents

The human body naturally produces the hormone called Melatonin; it simply doesn't make you sleepy but helps in the rise of the level of Melatonin, which makes your Wakefulness to get sleep, an average can last up to 30-60 minutes; pills like OTC Melatonin can stay 4 to 10 hours in the body. 

There are some natural ways to increase Melatonin, such as dime the lights during the night, reducing screen time, eating healthy foods, and improving relaxation by reducing stressful things. 

To overcome Insomnia, Trazodone is used to treat the problematic sleeping aid in patients; let us see more about Melatonin and Trazodone functions in detail.

What Is Melatonin?

Melatonin is a hormone produced by our body daily. It is responsible for influencing sleep cycles in our systems. Melatonin production in the body is sensitive to the amount of light our body is exposed to. It is high when there is no or very little light around us, and it falls when we are exposed to sunlight.

Many people who have Insomnia (problem sleeping or staying asleep) are recommended to take Melatonin as a supplement to aid in sleeping.

The chemical name for Melatonin is N-acetyl-5-methoxytryptamine. Many brands offer Melatonin supplements in the market. However, accessories from brands like Life Extension, Nature's Bounty, and Solgar are more popular.

Melatonin is taken in doses of 0.125mg, 0.3mg, 0.5mg, 2mg, 5mg and 5-10mg. 

What Is Trazodone (Desyrel)?

Trazodone is used to treat clinically diagnosed depression. It is an FDA-approved drug recommended for use in managing symptoms of depression. It is known in the market by familiar brand names like Desyrel, Desyrel divide, Oleptro, Trazodone D, etc. Along with treating symptoms of depression, it also helps improve mood, reduce Anxiety and treat Insomnia in patients prescribed it. 

Trazodone is available in doses of 50mg, 100mg, 150mg and 300mg. It is available in normal-release and extended-release forms as well. Extended-release formulations are ingested slowly into the body and thus provide a longer-lasting effect. You can also buy Trazodone online from a certified online pharmacy.

Frequently it is suggested by doctors to take Trazodone during bedtime.

How Does Melatonin Work?

Melatonin influences circadian rhythms and controls when we wake up or fall asleep. It is a sleep regulator and not a sleep initiator. The pineal gland naturally produces Melatonin inside the brain in our bodies. 

Melatonin supplements mimic the chemical compounds present in natural Melatonin and thus help achieve the same effect as the natural substance. Melatonin supplements take between 20 minutes to 2 hours to come into effect from the time of ingestion.

The common side effects are headache, dizziness, Nausea., irritability, diarrhoea, stomach cramps, constipation etc.
There is no recommended dosage format, but adults can take 1 to 5mg appears to be effective. You can take the drug before going to bed for effective results.
It is used for sleep issues; typically, sleeping aids can be used for more than two weeks with a prescription from your doctor. Like. Trazodone can be safely used for longer days.

How Does Trazodone Work?

Trazodone affects the balance of chemicals in the brain. Trazodone is said to increase serotonin levels in the patients using it.

Seratonin is a happiness hormone naturally available in our bodies. It helps regulate our mood and well-being. It impacts our perception of happiness and is a crucial hormone for a fulfilling experience.

 Trazodone contributes to increasing and maintaining serotonin levels in your system. This increase happens slowly over weeks. Thus Trazodone is said to improve mood, help control depression, and aid insomnia in patients prescribed to it. 

Is It Safe To Take Melatonin And Trazodone Together?

In some cases, patients with depression who are under treatment with Trazodone might still not be able to sleep and may want to explore taking Melatonin and Trazodone together to aid their Insomnia.

Melatonin and Trazodone together have not been shown to exhibit any drug interactions. Therefore if someone is taking Trazodone for sleep aid, taking Melatonin with Trazodone might be beneficial.

However, in a few people dealing with depression, Melatonin has been shown to increase their symptoms.

One must consider that both the drugs Melatonin and Trazodone have sedative effects, and overdosing can cause excessive drowsiness and headaches to some extent. Before taking this drug combination, you must consult a professional and try to avoid prolonged use. The only case where you can take these drugs together is when their benefits outweigh the potential risks. 

Thus taking Melatonin and Trazodone for sleep aid may be possible but is not recommended. People with depression should not take melatonin supplements due to the risk of depression symptoms worsening. You may try other combinations that have less risk to help you sleep. 

Side Effects Of Melatonin And Trazodone Togather

Short-term use of Melatonin supplements is entirely safe, but it is seen that taking more than recommended dose over a long period may result in various side effects, such as:

  1. Drowsiness
  2. Headache
  3. Excessive sleeping
  4. Bad dreams

Trazodone and other antidepressants have been shown to influence suicidal thoughts in young adults and children. Particularly patients below age 24 who were given Trazadone showed a rise in suicidal tendencies.

Other side effects of the drug include:

  1. Headache
  2. Nausea
  3. Vomiting
  4. Confusion
  5. Nightmares
  6. Muscle pain

Bottom Line From Practical Anxiety Solutions

Melatonin is a hormone created by our body every day. It is responsible for influencing sleep cycles in our systems. At the same time, Trazodchanceis used to minister clinically analysed depression. It is an FDA-approved medication suggested that helps in managing the manifestation of depression.

Patients with unhappiness who are treatment active with Trazodone might still be unable to rest and may want to investigate taking Melatonin and Trazodone jointly to cure their sleeplessness.
Before taking the medication, consult your doctor about your past and present health history to avoid adverse reactions to the drug. 

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