Osteoarthritis (OA) is the most common joint disorder affecting 32.5 million adults in the U.S. Among older adults, it is the leading cause of disability. The annual incidence of knee Osteoarthritis is highest between 55 and 64 years of age.
Osteoarthritis affects 13.9% of people over 24 and 33.6% over 64. Knee OA is the most common form. 19% of Americans over age 45 have knee OA. 62% of people with OA are women. In people younger than 45, OA is more common in men; over 45, OA is more common in women.
Tapentadol is a centrally-acting opioid analgesic to relieve moderate to severe acute pain in adults. Tapentadol acts by activating mu-opioid receptors and inhibiting norepinephrine reuptake.
As it is not a pro-drug and does not mediate its therapeutic effect via metabolism, Tapentadol is an alternative for patients who do not respond quickly to commonly prescribed opioid analgesics.
Moderate to severe pain, musculoskeletal pain, including neuropathic pain associated with diabetic peripheral neuropathy.
Osteoarthritis is a degenerative disorder of the joint in which joint tissue breaks down over time. People with OA usually have joint pain that stiffens briefly after rest or inactivity.
Osteoarthritis affects each person differently. In some people, osteoarthritis is moderate and does not interfere with everyday activities. In others, it causes severe pain and disability.
The most commonly affected joints in OA include:
Osteoarthritis occurs when the cartilage and other tissues within the joint break down or change structure.
Proper management of pain is crucial to the management of OA. Tapentadol is an innovative, dual-acting analgesic molecule combining two mechanisms of action: MOR agonism and NRI.
Its simultaneous reduction in adverse event burden is unprecedented and makes this drug particularly suitable for OA-associated pain, especially when a neuropathic component is present.
Tapentadol ER provided effective and well-tolerated treatment of severe chronic OA pain concerning the incidence of specific adverse events. The favorable tolerability profile supports Tapentadol ER as a treatment option before other opioids. Tapentadol appears to be a safe and effective therapeutic option for patients with severe OA pain.
Initial dose: 50 mg twice daily.
Continuation Dose: As early as one hour after the first dose
Immediate-release tablet or oral solution:
Exercise is considered a treatment for OA - perhaps the most effective treatment - rather than just a way to manage the condition.
Analgesics are medications used to relieve pain. Acetaminophen is a non-opioid analgesic that does not reduce inflammation or swelling but is helpful when pain is the main problem.
Nonsteroidal anti-inflammatory drugs help relieve joint pain, stiffness, and swelling. E.g., aspirin, ibuprofen, and naproxen sodium.
Corticosteroids can be injected into an affected joint to relieve pain and swelling. Hyaluronic acid therapy involves injecting the joint with a substance that occurs naturally in joint fluid and helps lubricate and cushion the joint.
The FDA has approved Duloxetine for chronic musculoskeletal pain.
Topical pain relievers are available as creams, gels, patches, rubs, or sprays. They contain salicylates, skin irritants, and local anesthetics to relieve pain. Some NSAIDs are also available by prescription for topical use.
Glucosamine and chondroitin sulfate are supplements that many believe relieve OA pain. Before taking these or other accessories, please discuss potential benefits and risks with your doctor.
Surgery may be helpful if your joints are severely damaged, you have severe joint pain, or you are disabled because of mobility problems. Different types of surgery are available for people with OA. It includes removing or replacing damaged cartilage or restoring all or part of the joint.
If you suffer from osteoarthritis, knowing how to manage your pain and schedule and plan your daily activities is vital. A better understanding of the disease and active management can improve your outcomes and quality of life.
Tapentadol ER provided effective and well-tolerated treatment of severe chronic OA pain concerning the incidence of specific adverse events. This drug might cause some negative effects, but it shows greater efficacy if taken in the prescribed manner.
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