Irfana
B.Sc (Psychiatry Ward)
19 August 2019 - 5 min read
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Cope Your Pain Induced Anxiety Using Tapentadol

It is a known fact that chronic pain causes anxiety regardless of where the pain is originated from.  Due to the increasing number of patients with chronic pain issues, healthcare service providers began to recommend Tapentadol, a novel drug with lesser potential for addiction. It has a dual set of mechanisms that affect the opioid receptors in the brain making the person feel relaxed with lesser painful sensations. 

Tapentadol for pain can be new for some folks, but its work on the chemicals of the brain can help in pain resolution. Tapentadol relaxes the nerves through his particular mechanism and helps to calm down the person going through pain.

Purchasing tapentadol through online sites has become a phenomenon behaviour of most peoples out there. Various pharmaceuticals provide fast and cost saving medicines at your doorstep or through your nearest pharmacies. Thus , keeping this in mind we have gathered such data to make your process of buying tapentadol easy and safe.       

What Is Nucynta (Tapentadol)?

Nucynta (Tapentadol) and Tramadol, an opioid pain medication called a narcotic, work to treat moderate to severe pain. The extended-release form of Nucynta (Tapentadol) (Nucynta ER) has been proven effective for constant, around-the-clock treatment of persistent or chronic pains that are not controlled by other medications. Nucynta (Tapentadol) is an opioid that should only be utilized for intense pain that retains non reacted well to different non-opioid discomfort drugs.

  • Common brand- Nucynta.
  • Drug class- opioid.
  • Control substance class- Schedule II.
  • Generic status – No lower-cost generic available.
  • Availability - Prescription only.

In 2008, the FDA approved Nucynta (Tapentadol) to treat all painful sensations arising from muscular disorder, muscle injury, or post-operative surgery. However, this approval is limited to short-term conditions. This restorative is only available with a prescription, which means one can buy this medication only if he/she has a proper prescription from a certified doctor. Without a prescription, this medicine is not available over the counter to be purchased. (Hartrick, C.T. and Rozek, R.J., 2011)

How Does Nucynta (Tapentadol) Work?

According to Riemsma, Rob, et al. “Systematic review of Tapentadol in chronic severe pain.” opioid painkillers like Tapentadol not only relieve pain but also mimic the action of naturally occurring chemicals called endorphins. Endorphins are found in the brain and spinal cord where they reduce pain by combining with receptors for opioids.

Nucynta (Tapentadol) is a synthetic opioid, similar to our natural endorphins. It works by blocking the transmission of pain signals sent along nerves from one part of your body to your brain and spinal cord—so even though you may still feel that same source of pain, it’s not as intense or bothersome.

The drug enhances the activity of a neurotransmitter called noradrenaline in the brain. Neurotransmitters are chemical compounds that act as messengers between nerve cells, and enhancing their effect helps relieve pain.

Dosing & Usages Of Tapentadol:

Immediate release: Schedule ll

  • 50mg
  • 75mg
  • 100mg

Extended Release: Schedule Il

  • 50mg
  • 100mg
  • 150mg
  • 200mg
  • 250mg

  Nucynta (Tapentadol) used for?

  • Acute (short-term) severe pain 
  • Chronic (long-term) severe pain  
  • Nerve pain from diabetes  

Acute-To-Severe Pain:

Immediate-release tablet or oral solution:

50-100 mg PO q4-6hr PRN; not to exceed 700 mg on day 1 and 600 mg/day & subsequently.

Extended-release tablet:

  • 50-250 mg PO q12hr PRN; not recommended to exceed 500 mg/day.
  • Opioid-naive patients: 50 mg PO q12hr; titrated to optimal dosage as prescribed; not recommended to exceed 500 mg/day.

If you accept the immediate-release tablet, your provider would determine the most appropriate dose for you depending on the amount of the immediate-release Nucynta (Tapentadol) you were taking.

Chronic Severe Pain:

Indicated for managing severe pain daily, around-the-clock treatment for which alternative options are inadequate.

50-250 mg PO q12hr; not recommended to exceed 500 mg/day.

If you were consuming the immediate-release tablet previously, your provider would determine the most appropriate dose for you depending on the amount of the immediate-release Nucynta (Tapentadol) you were taking.

Opioid-naive patients:

50 mg PO q12hr; titrated to optimal dosage as required; not recommended to exceed 500 mg/day.

Tapentadol IR takes about thirty minutes to release its effect after the single dose consumption. It stays up to twenty hours depending upon biological factors such as age, gender, and medical history. In contrast, the sustained release effects last for up to twelve hours, differing from person to person.

The average recommended dose of Tapentadol IR is 600 mg and Tapentadol ER is 500 mg/day. Do not exceed or decrease any of the doses without your doctor’s concern. It may lead to fatal issues in your body.

Drug Interactions of Nucynta (Tapentadol)

Tapentadol, when mixed with other drugs or food, may result in severe reactions. Opioids and benzodiazepines are two types of pain medications that can interact negatively, causing serious problems such as coma. Other inhibitors like methylene blue, linezolid, etc., can cause fatal consequences if combined with Tapentadol, resulting in death by the comatose state

If you have been on serotonin medications and then start taking Tapentadol, the chances of toxic interaction increase. Antidepressants are examples of SSRIs; talk to your healthcare physician before stopping the drug suddenly.

Some cold and flu medications can already make a person feel numb and exhausted. If you pair Tapentadol with any cough medications, then there might be a chance of over-drowsiness or sleepiness.

Involve into a habit of reading the label and the doctor’s prescription carefully; it will help you be aware of the ingredients present in the medication. And if you are already allergic to any of them, it would be easier for you to take alternative medications before starting the course.

One more vital thing is to complete the course as mentioned. Do not make any changes or stoppages in the dose without informing your doctor. Such self-decision may charge you a significant health penalty. (Singh, D.R., Nag, K., Shetti, A.N. and Krishnaveni, N)

Side Effects Of Nucynta (Tapentadol)

The usual change in the body was noticed in those who took Tapentadol immediate-release formulations. Nausea, drowsiness, vomiting, confusion, head pain, stomach upset, and frustration are some of the recurring common side effects observed among most Tapentadol users.

You don’t have to worry if these effects are concerning at a lower level. However, if you observe any of these causing you major trouble, then report to your immediate physician.

Suppose your body suffers from severe side effects such as confusion, fatigue, irregular breathing, sleep apnea, burning sensation while passing urine, loss of appetite, weight loss, weakness, or depression. Inform your doctor right away to take necessary preventive steps.

Seizure, light-headedness, faintness, irregular pulse rate, high blood pressure, hallucinations, major gastrointestinal issue, daytime sleepiness, and fever are some of the significant indicators that should be addressed on time.

Get healthcare service provider help right away if you find high allergic reactions such as severe skin rashes, swelling of the face, lips, tongue, and throat. Breathlessness and psychological disturbance are not the reaction to be ignored.

Tell your doctor immediately if you observe any of these effects or other ill reactions. As this is not the complete list, you should monitor and inform all discomforting sensations to your doctor.

Common side effects
Immediate-release:

  • Nausea 
  • Dizziness 
  • Vomiting 
  • Sleepiness 
  • Constipation

 Extended-release:

  • Nausea  
  • Constipation 
  • Dizziness 
  • Headache 
  • Sleepiness 
  • Fatigue 
  • Vomiting 

  Other Side Effects

  • Dry mouth
  • Upset stomach or indigestion
  • Poor appetite
  • Itching
  • Sweating
  • Anxiety
  • Difficulty sleeping
  • Tremor or shakiness

Is Nucynta (Tapentadol) Addictive?

Addiction can be a problem if opioids like Tapentadol are used for pleasure. But, for those who take it to relieve pain and not as a recreational drug, there is no likelihood of psychological addiction because the motive isn’t getting high from taking this medication.

A Research study by Vosburg, Suzanne K., et al. “Assessment of Tapentadol API abuse liability and addiction-related surveillance system.” Claims that Tapentadol, a Schedule II opioid, may be addictive if taken for an extended period. However, its withdrawal symptoms can generally be avoided by reducing treatment gradually.

It’s important to never take Tapentadol more than prescribed by your doctor, or for longer than they recommend. When stopping treatment always follow their instructions carefully.

SAFETY WARNINGS- 

One should not use Nucynta (Tapentadol) if he/she have…   

  • Severe asthma or breathing problems 
  •  Stomach or bowel obstruction 
  •  MAO inhibitor consumption 
  •  Head injury or brain tumor 
  •  Alcoholism and drug addiction 
  •  Urination problem 
  •  Liver or kidney disfunction 

Synopsis

Finding a legit pharma website can be tough one due to scam games, but these situations can be resolved by identifying the legitimacy through certifications. Generally opioids are best for pain reduction especially in trauma or other after effects of injuries. 

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