By Sudeshna Saha

Bachelor of Physiotherapy

09 December 2021
Medically reviewed by
Sumayya Salam
Pharm D
Does Wellbutrin Make You Hornier?
Table of Contents

Antidepressant Wellbutrin (bupropion) is used to treat the major depressive disorder and seasonal affective disorder. Wellbutrin isn't an SSRI and has no chemical similarity to any other antidepressant. While medical doctors are still unsure how and why Wellbutrin Make You Hornier, Wellbutrin can improve sexual pleasure isn't surprising.

The medication increases dopamine (a crucial neurotransmitter in the brain's reward system) activity. It is a controlled substance thats why it is not an OTC medication you will need a prescripiton to buy wellbutrin from any drug store. (McDANEL, D.L. and Horner, K.E., 2009). 

How Does Wellbutrin Make You Hornier?

Wellbutrin mode of action differs from that of an SSRI. Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) that raises dopamine and norepinephrine levels in the brain, which "reward" the pleasure centers following activities like eating and sex.

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Study on Wellbutrin With Sexual Side Effects:

According to a study conducted by the Department of Psychiatry, University of California School of Medicine, Los Angeles, California, USA.

Twenty-four people using serotonin reuptake inhibitors for depression who developed new sexual side effects after starting the medication were given increasing dosages of bupropion SR up to 300 mg daily for seven weeks. Women reacted 46 percent of the time, while men reacted 75 percent of the time. In both men and women, all sexual adverse effects improved in response to bupropion SR, with no difference in any one sexual side effect. The majority of the improvement (more than 50%) happened in the first two weeks and at a low dose (100-200 mg per day). Bupropion SR appeared to be beneficial in addressing all of the major types of sexual adverse effects when provided properly.

This resulted in Wellbutrin improving sexual wellness.(Hirschfeld, R.M., 2003)

Side Effects on Men:

Several case studies show that taking Wellbutrin has positive and negative impacts on male libido. The side effects are subjective.

Positive Effects:

  • Increased sexual arousal.
  • Increase in sexual ideation.

Negative Effects:

  • Reduction in sexual arousal.
  • Maintaining an erection is difficult.
  • Decrease in sex drive. 

Side Effects on Women:

According to various research, Wellbutrin's potential sexual adverse effects in women can range from minor to non-existent such as:

  • Reduction in sexual arousal.
  • Having a hard time climaxing.
  • Decrease in sex drive. 

Even at a low daily dose of 150 mg/day, people can utilize bupropion to boost their sex drive. However, make an appointment with your doctor first, since any changes in dosage can result in Bupropion overdose adverse effects. Bupropion takes a few months to enhance sexual life. Therefore patients should be watched by a medical practitioner and seek help during this time. It should also be mentioned that, despite the possibility of adverse side effects, one should never discontinue taking Wellbutrin suddenly.

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