Published on 01 February 2023

Wellbutrin For Erectile Dysfunction: What You Need to Know?

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One of the most prevalent illnesses affecting middle-aged and older men is erectile dysfunction (ED). It is a sentinel indicator for many reversible conditions, such as hypertension, diabetes mellitus, and peripheral and coronary vascular disease.

10% of males in the general population suffer from ED. It is anticipated that the prevalence of ED will have more than tripled globally between 1995 and 2025. Certain drugs, including numerous antidepressants, bring on roughly 25% of all occurrences of erectile dysfunction (ED).

Antidepressant side effects on sexual function can differ from person to person. They also depend on the individual medication taken and the dosage.

In contrast to SSRIs and SNRIs, Wellbutrin is an atypical antidepressant. Healthcare professionals commonly use Wellbutrin off-label to address conditions like ADHD, depression linked to bipolar illness, anxiety, and obesity. Wellbutrin, however, is also beneficial in an off-label setting for treating SSRI-induced sexual dysfunction brought on by antidepressants.

Like other antidepressants, does Wellbutrin also induce erectile dysfunction? How does it help to treat ED? Let's have a clear understanding.

What Is Wellbutrin?

Wellbutrin (Bupropion) is an atypical antidepressant for treating seasonal affective disorders and smoking cessation. The FDA approved it in 1985. Wellbutrin comes in both extended-release and sustained-release formulations. Wellbutrin is a prescription drug; you cannot buy Wellbutrin without a prescription from a licensed doctor.

Wellbutrin treats many conditions like sexual dysfunction, depression, weight gain, and smoking cessation.

Off-Label Indications

How Does Wellbutrin Work?

Wellbutrin works by raising the levels of dopamine and norepinephrine in your brain. Your body naturally produces these neurotransmitters to aid in transferring impulses from neuron to neuron in the brain. These impulses affect your thoughts, feelings, motivations, and mood.

Wellbutrin slows this process by which your brain breaks down the additional dopamine and norepinephrine, causing levels to rise in the brain. The slowing down boosts brain activity and helps lessen depressive symptoms.

Can Wellbutrin Cause ED?

One of the few antidepressants that don't appear to cause ED is Wellbutrin. There were no documented instances of ED during the Wellbutrin clinical trials. Additionally, studies have indicated that switching from an antidepressant that causes erectile dysfunction in men, Wellbutrin may cause the ED to go away. Wellbutrin might be a better alternative if your antidepressant led you to experience erectile dysfunction.

The prevalence of sexual side effects from Wellbutrin varies throughout numerous research. Wellbutrin, however, clearly has fewer sexual side effects than other antidepressants, including SSRIs, and is not frequently linked to ED.

Is Wellbutrin Used For Erectile Dysfunction?

There is evidence that Wellbutrin can enhance your sex life, which is even better news for people consuming the medicine. If you have ED, taking Wellbutrin may improve your erections, increase your sex drive and arousal, and improve your orgasms. Even when used daily, Wellbutrin boosted libido and sexual function in small double-blind research compared to placebos.

We can't draw firm conclusions about how Wellbutrin improves erections and sex because there is limited research in this area.

Can Wellbutrin Cause Sexual Dysfunction?

Research shows that Wellbutrin has a favorable effect on sexual dysfunction. Wellbutrin increases dopamine levels in the brain, which improves sexual function.

Wellbutrin has been studied as an addition to or a replacement for other antidepressants in patients with sexual dysfunction in numerous studies and brief, short-term trials. Wellbutrin appears to be a good treatment choice for sexual dysfunction.

In research by Clayton AH, 42 patients with SSRI-induced sexual dysfunction received either Bupropion SR or a placebo to treat sexual dysfunction. In addition to their SSRI, patients were randomly allocated to receive either bupropion SR 150 mg twice daily or a placebo for four weeks.

At week four, the results revealed a substantial difference between the two groups in sexual desire, with bupropion-treated patients showing more improvement over placebo-treated patients.

Frequently Asked Questions

A man with ED could feel emotionally aroused, but his penis might not be able to keep an erection for long. Frustration, inadequacy, emasculation, and shame may result from this. The person could worry that they can't satisfy their partner's sexual desires.
The duration of erectile dysfunction (ED) can range from months to years. You might have ED for the rest of your life, depending on the underlying cause.
Depending on the underlying cause, erectile dysfunction may be treated. Some ED-related factors are more straightforward to "treat" than others. However, ED may resolve with the correct diagnosis, assistance, and therapy.

Possible Side Effects

Side effects are undesired effects that occur after the administration of the drug. There are several significant side effects associated with Wellbutrin. These can range from mild to moderate and severe. Severe side effects include seizure episodes and an increase in suicidal thoughts.

Most of the common side effects include

  • Loss of appetite
  • Weight loss
  • Nausea
  • skin rashes
  • Sweating
  • Anxiety
  • Dizziness and
  • Trouble sleeping

Coping With Sexual Side Effects

According to research, these adverse sexual effects are common. Before receiving therapy, 35% to 50% of patients with depression who have not sought treatment also experience some form of sexual dysfunction. Antidepressant users experienced a marginally higher chance (71% vs. 65% in the untreated group) of developing the condition.

Strategies For Coping With Sexual Dysfunction

  • Communication

It can be awkward and difficult for people to tell their doctor or psychiatrist about their sexual problems. Recognizing that you have a problem and talking to your spouse about it, as well as your doctor or therapist, are the first steps you can take to address sexual dysfunction.

  • Schedule your sex:

Before choosing when to take your medication, consider your sexual behavior pattern. Your drug may have adverse effects that are more noticeable at specific times of the day, such as just after you take it. If so, consider scheduling your sexual activity for when side effects are at their least annoying, or take the medication at a different time.

  • Determine the root cause:

In some cases, sexual dysfunction may stem not from the SSRI but rather from the underlying condition or a medication. Age-related changes, chronic illness or pain, low libido, and life stressors can also impact your sex life.

  • Reduce the dose:

Sexual side effects could disappear with a lesser dose.

  • Changing to a different medication:

Some antidepressants, such as Wellbutrin and mirtazapine (Remeron), have a low tendency to induce sexual problems. Antidepressants like Trintellix have fewer sexual adverse effects.

  • Trying different approaches:

It may be worthwhile to try alternatives like psychotherapy, acupuncture, nutritional supplements, and more. Additionally, you can persuade your spouse to adopt some of these lifestyle modifications. To prepare for sex, you might try working out together or change your routine to include different forms of stimulation.

  • Taking a drug holiday

Depending on how long the drug typically stays in your system, you may stop taking medicine after a few days, such as before the weekend, only if you intend to have sex. Although this isn't a quick solution, it can work if you carefully adhere to your doctor's advice on when to stop and resume taking your prescription.

What Should You Do If Wellbutrin Causes ED?

You may start by waiting. Some side effects may disappear gradually as your body becomes used to the drug. You might discuss lowering your dose with your doctor if your ED continues.

Another choice is to continue taking Wellbutrin if it is improving your symptoms of depression, but also consider taking other alternatives after consulting with a doctor. Finally, you can use drugs like Viagra or testosterone supplements to address your erectile dysfunction directly.

You might also require a health examination to rule out any significant conditions and determine whether there is another factor contributing to your ED.

Can You Take Wellbutrin With A Blue Pill?

Viagra (sildenafil), commonly referred to as "the little blue pill," was the first phosphodiesterase 5 (PDE5) inhibitor approved to treat erectile dysfunction.

Now coming to the question-Yes, you can take Wellbutrin with the Blue Pill. While antidepressant drugs can help treat mental health issues like anxiety and depression, some medications can have undesirable consequences on the sex life, such as erectile dysfunction.

Viagra might be able to help with ED induced by antidepressants. According to data from pharmacokinetic investigations, sildenafil raised serum levels of Wellbutrin without changing their concentrations in the brain.

Drug Interactions

Drug interactions may cause the drug to be less or more effective or increase or decrease its action. Always discuss your medication history with your doctor before starting any new medication.

  • It can be risky to take Wellbutrin along with other drugs that reduce the seizure threshold. Amitriptyline, tramadol, clozapine, and other drugs fall within this category.
  • Levodopa and amantadine increase dopamine levels in the brain, similarly to Wellbutrin. Increased dopamine levels may cause toxicity in the brain.
  • Avoid taking MAO inhibitors during treatment with Wellbutrin. It may increase your blood pressure.
  • Combining Wellbutrin and alcohol may impair your brain and increase the likelihood of having suicidal thoughts or actions. Additionally, it could make you feel lightheaded and interfere with your ability to focus.
  • Other drugs that can affect Wellbutrin levels in the body include:
    • Clopidogrel
    • Efavirenz
    • Carbamazepine
    • Ritonavir
    • Phenobarbital

Also Read

Bottom Line From Practical Anxiety Solutions

Many people experience erectile dysfunction as a common side effect, which makes it harder for depressed people to take their medications as prescribed. The reality is that for many men who take antidepressants, erectile dysfunction frequently affects sexual activity.

The condition is increasingly widely acknowledged in contemporary society because of the availability of numerous remedies and growing public awareness of and societal acceptance of such treatments.

However, ED is more than just a sexual or lifestyle issue and may be a crucial early indicator of a more severe illness. Prescription drugs, lifestyle modifications, and therapy are the best ED treatments. Wellbutrin may be able to assist, but therapy for these problems may require more effort from you than merely trying a new drug.

If you're experiencing ED problems, a medical expert might advise making lifestyle adjustments, such as quitting smoking or drinking, abstaining from recreational drugs, improving your eating and exercise routines, and perhaps even getting more sleep.