IRFANA PARVEEN
By Irfana Parveen

B.Sc (Psychiatry Ward)

22 November 2021
Medically reviewed by
Sumayya Salam
Pharm D
How Long Does Trazodone Stay In Your System?
Table of Contents

Antidepressants drug works effectively to relieve the symptoms of depression and anxiety in people; they will work in the brain by changing the chemical present called a neurotransmitter.

Therefore experts say these are the leading cause responsible for mood and behaviour. There are many groups of antidepressant drugs available to treat the condition, 

Selective serotonin reuptake inhibitors (SSRI) are one of the antidepressant classes which help treat major depressive episodes.

Trazodone belongs to a group of antidepressants; thus, see more about it in detail 

What is Trazodone (Desyrel)?

Trazodone is an antidepressant from a class called serotonin receptor antagonist and reuptake inhibitors (SARI’s). Trazadone shares a lot of characteristics of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants. Trazadone is used to treat major depressive episodes in people.

Trazadone is used in adults and has proven to be effective compared to other types of antidepressant drugs in treating depression. Trazadone has a distinguishing factor: it does not stimulate sexual symptoms, anxiety symptoms, or insomnia, which are usually associated with selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine receptor inhibitors (SNRIs) therapies.

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It helps in improving the mood, appetite, and energy level while at the same time decreasing the anxiety and insomnia related to depression. It is not available over the counter though you can buy Trazodone online from certified online pharmacy.

Trazadone is an effective tolerated antidepressant in treating MDD (Major depressive disorder) both as monotherapy or even combination therapy (Haria, M., Fitton, A. and McTavish, D., 1994). 

Dosing Information In Adults:

INITIAL DOSAGE INCREASED/GENERAL DOSAGE MAXIMUM DOSAGE
150mg/day in divided doses 50mg/day for 3-4 days - 600mg/day(inpatients) - 400mg/day( outpatients

Regulation:

  • patients should take the drug shortly after a meal or light snack.
  • Dosage should be reduced after an adequate amount of positive response.
  • Patients should be transparent about their personal/family medical history related to bipolar disorder, mania, or hypomania before getting a prescription.
  • The patient should be monitored for withdrawal symptoms when discontinuing therapy.
While taking Trazodone, many factors say gaining extra weight by changes in the appetite, fat storage, and sedation lead to slowing the metabolism in the body.
This drug has the effect to lead serotonin syndrome; The risk will be higher if you consume with a higher dosage than recommended and take drugs together with similar products to Trazodone.
The drug is unsafe for people with heart disease, mental illness, pregnancy, or breastfeeding conditions. Consult with your doctor about your health before taking the medication.

How Long Does Trazadone Stay In Your System?

Trazadone isn’t a one-time drug; it is a treatment that may continue for days or weeks, depending on the severity. Following is the time taken to eliminate a single dose of Trazadone from your system.

After the initial dosage, it will take around one to three days for your body to eliminate the same dosage.

Half-life refers to the time taken by our body to reduce the drug level in the blood by half. The half-life of Trazadone is around 5 to 13 hours, meaning, every 5-13 hours, the Trazadone concentration in your blood will decrease by half. Depending on the half-life of Trazadone, it will take around 32 to 75 hours for the drug to be gone completely.

Although, the stay of Trazadone is not fixed and is influenced by various other factors such as,

  • Metabolism rate: the metabolism rate of the patient influences the time taken by the body to eliminate the drug. People with a slow metabolism rate will take longer to eliminate the drug from their system and vice-versa.
  • Age: the age of the person also affects the time Trazadone is in your system. Generally, it will take longer for elderly patients to eliminate the drugs compared to teenagers.
  • Weight: how long Trazadone stays in your system is also affected by your body fat percentage.
  • Frequency of the drug: the dosage amount prescribed to you also impacts the stay of the drug in your system. If your treatment is for an extended period at high dosages, then, in turn, the stay of trazodone will also expand

Usually, the smaller you are and the more of the drug you take, the longer the drug will be in your system. Doctors typically consider these factors in prescribing the dosage of the drug  

How Long Does It Take For Trazadone To Start Working In Your Body?

On average, Trazadone begins to relieve depression 1 to 2 weeks after your initial dose. However, Trazadone does not provide instantaneous results. It may take on average two weeks for the drug to completely set in.

In the initial treatment, patients may experience worsening symptoms. Common side effects of Trazadone include,

  • Headache
  • Nausea/Vomiting
  • Confusion
  • Dry Mouth
  • Muscle Pain

Other than these, there are a few severe symptoms one should look out for like,

  • Chest Pain
  • Fast, Pounding, Or Irregular Heartbeat
  • Loss Of Consciousness (Coma)
  • Fainting
  • Seizures
  • Shortness Of Breath
  • Unusual Bruising Or Bleeding.

Trazadone can cause painful erections in men, some cases may even involve surgical treatment, and there have been rare cases where permanent damage has occurred. Consulting a doctor about the risk of taking Trazadone is advisable. 

Bottom Line From Practical Anxiety Solutions

Trazadone is an effective drug to treat depression because it resembles a few characteristics of serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine receptor inhibitors (SNRIs). However, using this drug on a long-term basis may develop a dependence on the drug.

The patient becomes used to the drug, and it can get complicated for the patient to withdraw this medication after the treatment is complete. One should always consult a doctor before taking a prescription and be transparent about their personal/family medical history since Trazadone can also be fatal.

  •  Rawls, W. N. (2016). Trazodone (Desyrel, Mead-Johnson Pharmaceutical Division). Drug Intelligence & Clinical Pharmacy. From https://doi.org/10.1177/106002808201600102 Obtain on 30/08/2022
  • Khurana, R. C. "Treatment of painful diabetic neuropathy with trazodone." Jama 250.11 (1983): 1392-1392. From https://doi.org/10.1001/jama.1983.03340110016015 Obtain on 30/08/2022
  • Rickels, K., Schweizer, E., García España, F. et al. Trazodone and valproate in patients discontinuing long-term benzodiazepine therapy: effects on withdrawal symptoms and taper outcome. Psychopharmacology 141, 1–5 (1999). From https://doi.org/10.1007/s002130050798 Obtain on 30/08/2022
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