By Irfana
B.Sc (Psychiatry Ward)
01 December 2021 -
Medically reviewed by
D. Pharm
Can Imipramine Be Taken For Sleep?
Table of Contents

Imipramine is an antidepressant medication sold under the brand name Tofranil. It belongs to a class of drugs known as tricyclic antidepressants. It's used to treat depression, anxiety, panic disorders. It comes in the form of tablets and oral liquid medicine. you can also buy Tofranil online from a certified online pharmacy but it is recommended to get order doctor's advise first.

Imipramine is used for the treatment of depression, Anxiety, and bedwetting. It has not much to do with sleep. Relieve in the symptoms of depression can better the quality of sleep, but Imipramine alone cannot alter any changes when it comes to sleep insomnia. 


The Department of Psychiatry and Behavioural Medicine, Eastern Virginia Medical School, Norfolk, conducted a double-blind study comparing Trimipramine to Imipramine in depressed insomniac patients. 

Imipramine and Trimipramine are sedating a tricyclic antidepressants. This was a 4 week-long study conducted on patients with Insomnia and Anxiety. Trimipramine eliminated the signs of Insomnia, but the same can't be said for Imipramine. Although depression improved in both the medicine groups, the subject's sleep appeared to be unchanged or more disturbed. 

For Trimipramine, the significant changes in sleep were seen in the first week of the study, but since then the quality of changes gradually did not remain constant. Trimipramine did not improve the REM cycle in patients.(Soldatos, C.R., 1977)

By this study, we can conclude that:

  • Antidepressants' effect on sleep can vary even though they have the same impact on depression.
  • Reports of sleep by patients weren't standard; they changed after the first week, stating that these two medications have almost no effect on sleep.(Normann, C., Biber, K. and van Calker, D., 2015)

Alternatives To Imipramine: 

Since Imipramine cannot help with your sleep problems, here are a few effective drugs that can:

Side Effects Of Imipramine:

Imipramine can have a few side effects. Consult a doctor before taking it and after taking it if any side effects prevail:

  • Difficulty in urinating.
  • Dry mouth.
  • Nightmares.
  • Constipation.
  • Changes in sex drives.
  • Severe Rashes.
  • Irregular heartbeat.
  • Drowsiness.


  • Imipramine is used to treat Anxiety and Depression.
  • Imipramine helps relieve symptoms of Anxiety and Depression.
  • Imipramine doesn't cure Insomnia.
  • Other medications can help treat your sleep issues.
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