B.Sc (Psychiatry Ward)
19 August 2019 - 5 min read
Medically reviewed by
D. Pharm
Get Imipramine Online $0.40 without a prescription
Table of Contents

Clomipramine is a prescription medication, so you’ll need to consult a doctor before purchasing. Some companies have healthcare professionals on their team who can assess you before your purchase.

Online pharmacies can sell counterfeit medications, so it’s essential to do your research before buying from any retailer.

In 2014, the National Association of Boards of Pharmacy found that 97 percent of Trusted Source of the internet pharmacies it examined were not compliant with federal laws, state laws, or industry standards.

It’s a good practice to stay away from international websites, as each country has its governance in manufacturing. Stick to reputable sites and pharmacies you can trust.

Tofranil is a brand-name drug for the oral tablet Imipramine. It is a tricyclic antidepressant that is used to treat depression. Imipramine treats depression by working on your central nervous system, where it increases certain levels of natural substances like norepinephrine in your brain.

It is also used along with other treatments to prevent bed-wetting in children. There is not enough information on how Imipramine prevents bed-wetting; Some studies believe it works by preventing the impact of a certain substance called acetylcholine on the bladder. Imipramine can also be taken along with other medications as a part of combination therapy.(Gupta, V., 2021)

How to use Imipramine?

Imipramine is available as a tablet and a capsule for oral use. When used to treat depression, imipramine tablets or capsules are often taken one or more times per day, with or without meals. 

When used to prevent bedwetting in children, imipramine tablets are normally taken one hour before sleep. Take Imipramine at the same time every day if possible. 

Read all of the drug guides or instruction papers that came with your prescription and follow all of the instructions on the label. The doctor may need to adjust your dosage from time to time. Follow the medication’s instructions to the letter. If you’re having surgery, let your doctor know. If your symptoms worsen, contact your doctor.

This drug takes a while to take effect. If you’re taking this medicine for depression, it could take up to three weeks before you see the full effects. Even if you feel normal, keep taking this medication. Do not discontinue using this medication without first visiting your physician. When medicine is abruptly withdrawn, several conditions may worsen. It’s possible that your dose will need to be gradually reduced.

This medicine may not work as effectively in children who have been bed-wetting for a long time and may require different dosing. If this drug isn’t functioning as well as it used to, talk to your doctor.(Gupta, V., 2021)

Forms and Strengths

Imipramine is available in two forms – tablets and capsules

Tablet – 10mg, 25mg, 50mg

Capsule – 75mg


For depression

In adults

Initial dose – 75mgs per day

Maximum dose – should not exceed 200mg

In teenagers and older adults

Initial dose – 30 to 40mg per day 

Maximum dose – should not exceed more than 100mg

For enuresis (children 6 years of age and older) 

Initial dose – 25mg 1 before bedtime. Your doctor may adjust the dose if needed. 

Side Effects Of Imipramine

Side effects of this drug may slightly vary in adults and children

Some of the common side effects in adults include: 

  • Nausea
  • Drowsiness
  • Weakness or tiredness
  • Excitement or anxiety
  • Dry mouth
  • Skin more sensitive to sunlight than usual
  • Changes in appetite or weight
  • Constipation
  • Difficulty urinating
  • Frequent urination
  • Changes in sex drive or ability
  • Excessive sweating

Side effects in children include: 

  • Nightmares
  • Stomach cramps
  • Tiredness
  • Nervousness
  • Stomach pain 

Contact your medical professional if the side effects are severe and do not go away for a long time 

Serious Side Effects

You should let your pharmacist or healthcare professional know immediately if you think you are experiencing serious side effects or if you think your symptoms seem life-threatening.

Some of the serious side effects include:

  • Aggression 
  • Uncontrollable shaking of a part of body 
  • Difficulty breathing 
  • Dangerous impulses 
  • Worsened depression 
  • Worsened anxiety 
  • Hallucinations
  • Eye pain or swelling 
  • Panic attacks
  • Trouble sleeping 
  • Yellowing of the skin or eyes


Your medicines may be harmed if they come into direct contact with heat, air, or light. The exposure of medicine to the environment may have certain negative consequences. Generally, the medicine should be maintained between 68°F and 77°F (20°C and 25°C) at room temperature. The medicine must be stored out of reach of children in a secure location. Because many prescription containers are not child-resistant and small children can readily open them, it is critical to keep all medication out of sight and reach of children.

Interactions With Other Drugs 

Sleepiness can be exacerbated if you combine Imipramine with other sleep-inducing medications. Before taking Imipramine with a sleeping pill like Zopiclone, narcotic pain medicine, muscle relaxers like Carisoprodol or anxiety, depression, or seizure medicine, consult your doctor.

Imipramine has the potential to interact with a wide range of drugs. Prescription and over-the-counter medications, vitamins, and herbal products are all included. If you’re taking any other medications, tell your doctor.

Things To Avoid While Taking Imipramine 

Do not consume alcoholic beverages. When alcohol is mixed with Imipramine, dangerous adverse effects or death can ensue. Also, Avoid driving or engaging in dangerous activities until you have a better understanding of how Imipramine will impact you. It’s possible that your reactions will be hampered. Avoid being exposed to the sun. Imipramine can make you more susceptible to sunburn. When you’re outside, wear protective gear and apply sunscreen.(Gittelman-Klein, R. and Groff, S., 1974)

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