Muscle spasms are a pain in the muscle area; you may notice any hard pain under your skin tissues. Muscle spasms are caused by the overuse of the power, giving strain or pressure to the forces. Or due to any underlying disease.
Although 60./. To 85./. are affected by Muscle spasms in the US. It is a widespread problem. Some common sites for muscle spasms include thighs, feet, calves, arms, hands, arms, and abdomen.
There are some natural ways to relieve muscle spasms, but When it comes to the medication, Diazepam is used to treat muscle spasms caused by inflammation or trauma. It is very effective in treating muscle spasms. Let us now understand more about the function in detail,
What is Valium?
Diazepam (Valium), introduced in the 1960s, is a member of the drug class benzodiazepines. Compared to other drugs in treating Anxiety, they are generally safe medications. Despite being widely accessible and having a comprehensive therapeutic Index, Diazepam has the potential to be abused.
Mechanism Of Valium
The benzodiazepine receptors that Diazepam binds appear to undergo allosteric modifications, which make it easier for GABA to bind to its receptor. It facilitates GABA activity in the neurotransmitter of the central nervous system. As a result, Chloride channels are opened, allowing for chloride input and improved postsynaptic neuron inhibition.
Indications Of Valium
- Valium is used to treat Anxiety.
- It also functions as a muscle relaxant for a variety of conditions.
- Additionally, it has sedative, hypnotic, and anticonvulsant properties (e.g., for status epilepticus and drug-induced seizures).
- Alleviate the symptoms of cholinesterase poisoning, drug withdrawal, antihistamine overdose, Black Widow spider envenomation, and chloroquine overdose.
- Used as an anesthetic alone or with other medications to induce conscious sedation.
Dose And Dosage Forms
Valium can be given by mouth, slow IV injection, IV infusion, suppository, or rectal solution.
- For the greatest possible positive effect, dosage should be individualized.
- Depending on the indication and severity, the average dose for older children and adults is 2 to 20 mg IV.
- Patients who are elderly or disabled should receive lower doses, often 2 to 5 mg.
What Is Muscle Spasm?
A muscle spasm is an abrupt, involuntary contraction of one or more muscle groups. It is typically a serious condition brought on by a strained or sprained muscle (partial or complete rupture of a ligament).
Fibromyalgia, tension headaches, myofascial pain syndrome, and low back or neck pain are some musculoskeletal diseases resulting in soreness and muscle spasms.
How Does Valium Work In Muscle Spasms?
Benzodiazepines have been used as muscle relaxants for spasticity in tetanus, cerebral palsy, and stroke. Benzodiazepines cause presynaptic inhibition and decrease mono and polysynaptic reflexes by increasing gamma-aminobutyric acid (GABA) affinity for GABA-A receptors.
The most widely used benzodiazepine for the management of spasms is Diazepam. Research has shown that benzodiazepines' muscle-relaxing effects result from central rather than peripheral effects. Diazepam reduces reflexes in the brainstem and spinal cord. It might also have an impact on a muscle's ability to contract.
The effects of Diazepam last a very long time. One hour after oral dosing, diazepam levels peak due to quick absorption of the drug. The liver converts it to the active substances Lorazepam and oxazepam. The muscle-relaxant effects of Diazepam are perhaps superior to those of other benzodiazepines.
Studies Related To Valium Use In Muscle Spasms
- In Srivastava's study, increased doses of morphine combined with Diazepam to treat pain reduced muscle spasms. Within 24 hours after the start of the diazepam treatment, the severity and frequency of muscle spasms decreased. Five days after the initiation of the diazepam medication, there was an adequate improvement in symptoms.
- In 1967 COOK AND NATHAN concluded that whatever effect benzodiazepines have on the brain, at least some of their ability to reduce spasticity is a result of their actions on the spinal cord. It is currently thought that the drug's ability to stop or reduce the excessive motor activity of many distinct illnesses is caused by the same degree of action in all of them; the spinal cord is where all movements are ultimately organized.
- Schmidt and his colleagues showed that Diazepam increased presynaptic inhibition and gave the first hint as to how the BZDs worked.
Side Effects Of Valium
Common side effects include:
- feeling tired,
- muscle weakness; or
- problems with balance or muscle movement.
Other medications used in the treatment of Muscle Spasms
- Baclofen and dantrolene are additional muscle relaxants for muscle spasticity.
- Baclofen is a GABA agonist that causes presynaptic inhibition, inhibiting mono and polysynaptic reflexes.
- Dantrolene exerts its antispasticity effects directly on skeletal muscle, resulting in muscle weakness.
- Other benzodiazepines frequently used in general medical practice include Lorazepam, midazolam, and
- Progabide: According to early data, the investigational medicine progabide, a GABA agonist with systemic activity, can lessen some spasticity symptoms.
Bottom Line From Practical Anxiety Solutions
Diazepam slows down the spinal cord and brainstem reticular formation's motor circuits to create calming effects. Diazepam has an active role in treating muscle spasms. It belongs to the benzodiazepines group, usually a sedative drug that helps slow down the brain and the body; it increases neurotransmitter activity to decrease muscle spasms.
Take Diazepam exactly as your healthcare provider tells you to take it. Despite helping treat spasticity, Diazepam needs to be used carefully.
- Srivastava, M., Walsh, D. Diazepam as an adjuvant analgesic to morphine for pain due to skeletal muscle spasm. Support Care Cancer 11, 66–69 (2003). From https://doi.org/10.1007/s00520-002-0386-8 Obtain on 12/10/2022
- Nathan, P.W., 1970. From https://doi.org/10.1016/0022-510X(70)90090-0 Obtain on 12/10/2022
- Sohn, D. M. (1975). Valium.. Anesthesia Progress, 22(3), 74-77. From https://doi.org/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516718/ Obtain on 12/10/2022
- Simons, D., & Mense, S. (1998). Understanding and measurement of muscle tone as related to clinical muscle pain. Pain, 75(1), 1-17. From https://doi.org/10.1016/S0304-3959(97)00102-4 Obtain on 12/10/2022