By Irfana
B.Sc (Psychiatry Ward)
28 April 2022 -
Medically reviewed by
Sumayya
D. Pharm
How long Does Ativan Stays in the System?
Table of Contents

Ativan, known by its generic name lorazepam, is a benzodiazepine medication used to treat anxiety disorders, trouble sleeping, severe agitation active seizures. Ativan works by interfering with the brain and nerves to produce a calming effect.

It takes around sixty hours for a patient to completely cleanse the drug from the body.

It is not available over the counter though you can buy Ativan online from a certified online pharmacy it is recommended to get a doctor's prescription first.

Ativan half-life:

Half-life means the amount of time taken by the body to eliminate the strength of a single dose of the drug by 50%. The average half-life of the drug Ativan is 12 hours.

Ativan is broken down into metabolites by the liver. This breakdown product carries a half-life of 18 hours.

Mixing Ativan with other drugs also influences the half-life of the drug. For example, the medicine probenecid can increase the half-life of the drug Ativan while the asthma drug theophylline can decrease it. (Work, H.D.A., Ativan (Lorazepam).)

Factors that influence the stay of Ativan:

The duration for which Ativan stays in the body is impacted by a variety of factors, including:

  • Dosage: The larger the Ativan dose, the longer it may take for the drug to leave the body. This is because the liver will take a longer time to cleanse.
  • Usage frequency: The more Ativan a person takes, the longer it may take for their body to eliminate the medicine.
  • Method of administration: Ativan is usually taken as a tablet or a liquid, but it can also be given as an injection. Although the medicine has the same effects, whether taken by mouth or by injection, each person's body may process the drug differently.
  • Age: People in the age group of the 80s-90s usually take 20% more time to cleanse the drug as compared to the younger age group

Ativan drug testing: 

Numerous tests can be used to determine whether or not lorazepam is present in your body. Depending on what is being examined, Ativan can show up on tests for various amounts of time.

  • Urine tests: Ativan can be discovered in the urine for three to six days after usage, and it appears in urine about two hours after use. A common way to test for Ativan is through urine tests.
  • Hair tests: Ativan does not often show up in hair tests, and when it does, it is usually at low concentrations.
  • Saliva test: Saliva testing suggest that Ativan appears in the saliva about 15 minutes after consumption and can last for up to eight hours.

Study:

Aim: To determine the Single- and multiple-dose kinetics of oral lorazepam in humans

Method: Single- and multiple-dose kinetics of oral lorazepam in humans and were given 4mg oral doses of lorazepam

Findings: Within 3 hours of a single 4-mg oral dose, peak plasma lorazepam concentrations ranging from 40 to 70 mg/ml were obtained. The average absorption half-life was 25 minutes (range 10.3-42.7 minutes), and the average elimination half-life (t1/2 beta) was 14.2 hours (range 8.4-23.9 hr.). Accumulation to the steady-state condition was completed within a few days of starting medication after 15 days of 3 mg per day delivered in divided doses. The accumulation half-life was slightly longer than t1/2beta (mean 21.1 hr.), and the two were not closely associated.

Conclusion: The single-dose kinetic research accurately predicted the rate and extent of lorazepam buildup during multiple dosages. However, it was not always possible to make an accurate prediction for a single individual. Because single-dose t1/2beta and washout half-life values were practically identical, lorazepam stimulation or inhibition of its clearance is insufficient to explain the inaccurate prediction. (Greenblatt DJ, Allen MD, MacLaughlin DS, Huffman DH, Harmatz JS, Shader RI. J Pharmacokinet Biopharm. 1979 Apr)

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