By Nasrin
B. A. Psychology
07 April 2022 -
Medically reviewed by
D. Pharm
Can I take Melatonin with Trazodone for sleep?
Table of Contents

What is Melatonin?

Melatonin is a hormone produced by our body on a daily basis. It is responsible for influencing sleep cycles in our systems. Melatonin production in the body is sensitive to the amount of light that our body is being exposed to. It is high when there is no or very little light around us, and it falls when we are exposed to sunlight.

Many people who have Insomnia (problem sleeping or staying asleep) are recommended to take Melatonin as a supplement to aid in sleeping.

The chemical name for Melatonin is N-acetyl-5-methoxytryptamine. Many brands offer melatonin supplements in the market. However, supplements from brands like Life Extension, Nature’s Bounty, Solgar are more popular.

Melatonin is taken in doses of 0.125mg, 0.3mg, 0.5mg, 2mg, 5mg and 5-10mg (Hardeland, R., Pandi-Perumal, S.R. and Cardinali, D.P., 2006.)

What is Trazodone:

Trazodone is used to treat clinically diagnosed depression. It is an FDA-approved drug recommended for use in managing symptoms of depression. It is known in the market by familiar brand names like Desyrel, Desyrel dividose, Oleptro, Trazodone D, etc. Along with treating symptoms of depression, it also helps improve mood, reduce anxiety and treat Insomnia in patients who are prescribed it.

Trazodone is available in doses of 50mg, 100mg, 150mg and 300mg.It is available in normal release and extended-release forms as well. Extended-release formulations are ingested slowly into the body and thus provide a longer-lasting effect. you can also buy Trazodone online from a certified online pharmacy.

Frequently it is suggested by doctors to take Trazodone during bedtime. (Haria, M., Fitton, A. and McTavish, D., 1994.)

How does Melatonin work:

Melatonin works by influencing circadian rhythms in the body and controls when we wake up or fall asleep. It is a sleep regulator and not a sleep initiator. The pineal gland naturally produces Melatonin inside the brain in our bodies. 

Melatonin supplements mimic the chemical compounds present in natural Melatonin and thus help achieve the same effect as the natural substance. Melatonin supplements take somewhere between 20 minutes to 2 hours to come into effect from the time of ingestion.

How does Trazodone work:

Trazodone affects the balance of chemicals in the brain. Trazodone is said to increase serotonin levels in the patients who are using it.

Seratonin is a happiness hormone naturally available in our bodies. It helps regulate our mood and well-being. It impacts our perception of happiness and hence is a crucial hormone for a fulfilling experience.

 Trazodone contributes to increasing and maintaining serotonin levels in your system. This increase happens slowly over weeks. Thus Trazodone is said to improve mood, help control depression, and aid insomnia in patients prescribed to it.

Side effects of Melatonin and Trazodone:

Short term use of Melatonin supplements is entirely safe, but it is seen that taking more than recommended dose over a long period may result in various side effects such as:

  1. Drowsiness
  2. Headache
  3. Excessive sleeping
  4. Bad dreams

Trazodone and other antidepressants like it have been shown to influence suicidal thoughts in young adults and children. Particularly in patients below age 24 who were given Trazadone showed a rise in suicidal tendencies.

Other side effects of the drug include:

  1. Headache
  2. Nausea
  3. Vomiting
  4. Confusion
  5. Nightmares
  6. Muscle pain

Is it safe to take Melatonin and Trazodone together:

In some cases, patients with depression who are under treatment with Trazodone might still not be able to sleep and may want to explore taking Melatonin and Trazodone together to aid their Insomnia.

Melatonin and Trazodone together have not been shown to exhibit any drug interactions. Therefore if someone is taking Trazodone for sleep aid, taking Melatonin with Trazodone might be beneficial.

However, in a few people dealing with depression, Melatonin has been shown to increase their symptoms.

One must consider that both the drugs Melatonin and Trazodone have sedative effects, and overdosing can cause excessive drowsiness and headaches to some extent. You must consult a professional before taking this drug combination, and you must try to avoid prolonged use. The only case where you can take these drugs together is when their benefits outweigh the potential risks. 

Thus taking Melatonin and Trazodone for sleep aid may be possible but is not recommended. People with depression should not take melatonin supplements due to the risk of depression symptoms worsening. You may try other combinations that have less risk to help you sleep. (Taziki, S., Sattari, M.R. and Eghbal, M.A., 2013.)

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