By Irfana
B.Sc (Psychiatry Ward)
06 December 2021 -
Medically reviewed by
D. Pharm
Can You Use Venlafaxine For Hot Flashes?
Table of Contents

A Venlafaxine is an antidepressant that is part of the selective serotonin and norepinephrine reuptake inhibitors class of medicines (SSNRIs). It influences brain chemicals that may be out of balance in people who are depressed. It is a medication used to treat severe depression, anxiety, and panic attacks.

A hot flash is a sudden feeling of warmth in the upper body, mainly in the face, neck, and chest. It's likely that your skin will flush, giving the impression that you're blushing. Another symptom of a hot flash is sweating. 

Hot flashes are usually caused by menopause, while other medical issues can also cause them. Venlafaxine has also been shown to help with vasomotor symptoms in addition to depression symptoms. It's becoming more popular as a nonhormonal treatment for hot flashes, especially among women concerned about or have contraindications to estrogen-containing medications.

Although estrogen has been used to treat hot flashes for many years, the Women's Health Initiative trial findings have raised concerns about its safety. Newer antidepressants are being researched as a potential treatment for hot flashes.

Venlafaxine is a newer antidepressant that has also been used to treat hot flashes in cancer survivors and postmenopausal women without using hormones. In perimenopausal women with depression, venlafaxine has been shown to affect vasomotor symptoms positively. (Loibl, S., Schwedler, K., Von Minckwitz, G., Strohmeier, R., Mehta, K.M. and Kaufmann, M., 2007)

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Venlafaxine (Effexor XR)



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Forms And Strength

Immediate release oral tablets - 25 mg, 37.5 mg, 50 mg, 75 mg, 100 mg

Extended release oral tablets - 37.5 mg, 75 mg, 150 mg, 225 mg


The recommended starting dose of venlafaxine is 75 milligrams per day. This could be increased to a maximum amount of 375mg over time. If you have liver or renal problems, your doctor may prescribe a lesser dose.

Venlafaxine is not available over the counter you should always consult your health care provider before consuming these medicine. Order Venlafaxine online  from a certified online pharmacy.

Venlafaxine pills and capsules are available in both immediate and extended-release formulations. The way you take them is determined by the type you've been given. (Rudolph, R.L., Fabre, L.F., Feighner, J.P., Rickels, K., Entsuah, R. and Derivan, A.T., 1998)

For Depression

Immediate Release - 

Initially, take 75mg/day every 8 to 12 hours; may be increased by 75 mg/day no more than once every four days.

Moderate: 225 mg/day, split every 8-12 hours orally

Severe: 375 mg/day, split every 8-12 hours orally

Extended-Release - 

Initially, take 37.5-75 mg orally once daily; after four days, increase by 75 mg/day; do not exceed 225 mg/day.

For Hot Flashes 

Immediate Release - 

Take 75 mg once/day; alternatively, titrate up to 75 mg daily after one week of 37.5 mg once/day.

Extended-Release - 

For 4-12 weeks, take 37.5-150 mg orally once a day.

Side Effects 

  • constipation
  • diarrhea
  • Gas
  • A region of the body is experiencing pain, burning, numbness, or tingling
  • hot flashes
  • frequent urination
  • ringing in the ears
  • changes in sexual desire or ability
  • heartburn
  • burping
  • dry mouth
  • change inability to taste food
  • loss of appetite
  • weight loss

Drug Interactions

When you combine venlafaxine with other sleepy medicines, side effects can be amplified. Consult your healthcare professional before taking an opioid prescription, a sleeping drug, a muscle relaxant, or a treatment for anxiety or seizures.

 Venlafaxine should not be combined with any other antidepressants, St. John's wort, tryptophan, diet pills, weight loss drugs, blood thinners, mood, thought, mental illness medicines, or migraine headaches treatments.

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