Published on 06 February 2023

Zopiclone And Diazepam: Can You Take Them Together?

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Many people experience sleep-related problems. Sleep disorders affect the timing, and quality of sleep, causing daytime distress and functional impairment. Sleep-wake difficulties frequently co-occur with medical symptoms or other mental health issues, like anxiety, depression, or cognitive disorders. There are numerous sleep-wake disorders, with insomnia being the most prevalent.

Sleep disorders should be carefully addressed regardless of any possible mental or other physical issues. Treatment for chronic insomnia usually consists of both behavioral therapy and sleep aids. In some instances of insomnia, sleep aids may be beneficial. Zopiclone and Diazepam are both used to treat sleep difficulties in people.

The Z-drug Zopiclone is a short-acting hypnotic that acts on the same receptor as benzodiazepines but without the latter's apparent risk of abuse and potential for dependence. It was first made available as an insomnia medication in the second half of the 1980s.

Diazepam, sold under Valium, is a benzodiazepine medication with anxiolytic properties. It frequently treats a variety of ailments, including anxiety, seizures, alcohol withdrawal syndrome, benzodiazepine withdrawal syndrome, muscle spasms, insomnia, and restless legs syndrome. Let us look in detail at how both of these drugs work.

What Is Zopiclone?

Zopiclone is a nonbenzodiazepine drug class used for the short-term treatment of insomnia, where sleep initiation or maintenance are prominent symptoms. It was developed as a safer alternative to benzodiazepines which can be highly addictive. Its use can lead to dependence. Due to its addictiveness, one cannot buy Zopiclone online or from a local drug store without a prescription in the United Kingdom.

It is frequently referred to as a short-acting hypnotic due to how quickly it leaves the body. Its "half-life" is approximately 5 hours. Given the possibility of tolerance, dependency, and addiction, prolonged usage is not advised.

How Does Zopiclone Work?

Zopiclone has hypnotic, anxiolytic, anticonvulsant, and myorelaxant characteristics, making it a useful therapeutic drug. Zopiclone works by binding to the benzodiazepine receptor complex and modifies the macromolecular complex of the GABAB receptor chloride channel.

Both Zopiclone and benzodiazepines act indiscriminately at the benzodiazepine binding site on GABAA-containing ? 1, ?2, ?3, and ? 5 receptors, increasing the inhibitory effects of GABA to generate the therapeutic (hypnotic and anxiolytic) and adverse effects of Zopiclone.

What Is Diazepam?

Diazepam is a benzodiazepine derivative with anxiolytic properties. First patented and marketed in the United States in 1963, it is a fast-acting, long-lasting benzodiazepine. Diazepam is a controlled substance in the USA, and you will always need a prescription to buy Diazepam.

Valium helps in the management of anxiety, alcohol detoxification, sleep disorders, muscle spasms, preoperative anxiety relief, control of certain refractory epilepsy patients, adjunct in severe recurrent convulsive seizures, and an adjunct in status epilepticus.

ICU sedation and short-term spasticity treatment for cerebral palsy children are the off-label uses for Diazepam.

How Does Diazepam Work?

Benzodiazepines promote GABA activity at numerous places to provide their desired effects. Specifically, benzodiazepines bind at an allosteric location at the GABA-A receptor chloride ion channel's junction between the alpha and gamma subunits.

This Diazepam binding at the GABA-A receptor increases the frequency at which the chloride channel opens, increasing the conductance of chloride ions. The neuronal membrane becomes hyperpolarized due to this charge shift, lowering neuronal excitability.

Mainly, the anxiolytic effects of Diazepam are via the allosteric binding in the limbic system. The principal mediator of the myorelaxant effects of Diazepam is allosteric binding within the spinal cord and motor neurons. Receptors moderate Diazepam's sedative, amnestic, and anticonvulsant actions.

Frequently Asked Questions

In general, Zopiclone is thought to be safer than benzodiazepines. The short-acting hypnotic benzodiazepines and Z-drugs differed little regarding clinical efficacy and adverse side effects.
Patients with chronic pain who have insomnia respond better to Zolpidem than Zopiclone.
It speeds up the process of falling asleep and prevents nighttime awakenings. It affects the brain's gamma-aminobutyric acid, producing calming effects.

Can You Take Zopiclone And Diazepam Together?

Taking the two drugs together is unsafe as it may increase the effect of the other, causing central nervous system depression.

Study Related To The Effect Of Zopiclone And Diazepam Use

In a randomized, double-blind crossover study, the effects of equipotent, single intravenous doses of Zopiclone (7.5 mg) and Diazepam (10 mg) on ventilatory responses in healthy volunteers (aged 40 to 60 years) were examined. A healthy volunteer group of five men and five women participated in this five-day trial.

Each patient randomly received one intravenous dosage of Zopiclone (7.5 mg) or Diazepam (10 mg), with at least three days between injections. Early in the afternoon, ventilation parameters were recorded both before and after the injections.

No significant alterations that might have been caused by a drug's depressive effect on unstimulated breathing were seen. During the first and second rebreathing procedures, total ventilation was considerably higher after Zopiclone than after Diazepam.

Additionally, total ventilation was lower after Diazepam during the second rebreathing process than during the analogous control procedure. Following the injection of both drugs, blood pressure slightly decreased, but heart rate was unaffected.

Following the injection of the medications, all participants exhibited a similar degree of drowsiness. After receiving a dose of Diazepam, one individual immediately had coarse bilateral tremors of the extremities. In about 5 minutes, this effect subsided.

Following Diazepam injections, two people experienced mild to moderately painful phlebitis close to the injection site. The Diazepam injection caused local pain in three patients. Following the injection of Zopiclone, there was no local reaction.

Side Effects Of Consuming Zopiclone And Diazepam Together

Side effects are unwanted effects of the drug that occur after consumption. The reactions can be mild, moderate, or severe. The severity of adverse effects can be increased when Diazepam is combined with Zopiclone. Using Diazepam with Zopiclone may increase side effects such as:

  • Dizziness
  • Drowsiness
  • Confusion
  • Difficulty concentrating
  • Impairment in thinking, judgment, and motor coordination 

Zopiclone Or Diazepam, Which Is More Addictive?

Zopiclone is closely related to Diazepam and works similarly to other benzodiazepines. But Zopiclone may be more addictive than Diazepam. Those with a history of mental disorders or substance abuse may be at an increased risk of high-dose zopiclone misuse.

Withdrawal Symptoms

It is a term for the physical and mental symptoms someone experiences when they abruptly discontinue or reduce their use of an addictive substance.



Sleep difficulty

Abdominal cramps

Feeling anxious or tense



Tremors, sweating




Muscle pain

Paranoia- thinking other people want to harm you


Feelings of dissociation

Confusion and severe anxiety

Abnormal sensory perceptions

Muscle twitching


Restlessness and insomnia


Numbness and weakness

Muscle aches, spasms

Panic attacks and memory issues

Symptoms that mimic flu

Sensory hypersensitivity

Drug Interactions

As every medicine cannot be taken combined with other drugs. Interactions result in increasing or decreasing the effect of drugs. These can be mild, moderate, or serious interactions.

Drug Interactions Of Zopiclone

  • Combining Zopiclone and alcohol may have additive CNS depressant effects.
  • Zopiclone may have additional CNS depressant effects when used with sedative antihistamines, anticonvulsants, narcotic analgesics, anesthetics, or psychiatric drugs.
  • The concurrent use of benzodiazepines or other CNS depressants, including Zopiclone and opioids, increases the risk of profound sedation, respiratory depression, coma, and death due to the additive CNS depressant action. Use these medications concurrently only when other treatment choices are insufficient for the patient.
  • When co-administered with CYP3A4 inhibitors, including erythromycin, clarithromycin, ketoconazole, itraconazole, and ritonavir, Zopiclone may need to be given at a lower dose.

Drug Interactions Of Diazepam

  • Using benzodiazepines and opioids increases the risk of respiratory depression due to their actions at different receptor sites in the CNS that control respiration.
  • Concomitant use of Diazepam with alcohol may enhance the sedative effect.
  • Combined use of phenytoin and Diazepam may decrease the metabolic elimination of phenytoin by Diazepam.

Also read

Bottom Line From Practical Anxiety Solutions

Diazepam is a benzodiazepine derivative with anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, anti-tremor, and amnestic effects.

Zopiclone has comparable pharmacology to benzodiazepines while being chemically separate from them and attaching near to the same region of the GABA receptor-chloride channel complex. Several adverse effects, including visual disruption and hallucinations, have been reported despite its selective interaction with receptors.

Additionally, both impacts on recent or distant recall and impairment of psychomotor function may be considerable. Before prescribing hypnotics, it is essential to identify and treat the causes of insomnia, such as psychiatric conditions and physical illnesses. Get in touch with your doctor for clear guidance.