By Irfana
B.Sc (Psychiatry Ward)
18 May 2022 -
Medically reviewed by
D. Pharm
Can you take Ibuprofen with Valium?
Table of Contents

No interactions were found between Ibuprofen and Valium, but this doesn't mean that interaction is not possible between them.

So it's always better to consult your healthcare provider before consuming them together to know the detailed information about their Pros(uses) and Cons(risks).

Ibuprofen is a painkiller, while Valium is an anxiety medication. Both the medications are opposite from each other, and both treat different conditions.

If they are used together continuously it may show dangerous or life-threatening effects on your body.

But let's see in detail about both the medication and

What are the Effects of taking them together?

Ibuprofen-common and effective pain reducer

Ibuprofen is a prescribed drug and is also available as OTC medication in the form of painkillers. Ibuprofen is a Non Steroidal anti-inflammatory(NSAIDs) drug which is sold under the brand name Advil, Motrin, Nuprin, etc.

Ibuprofen is used to ease mild to moderate pain and reduce fever, inflammation and swelling. Ibuprofen is an overall treatment of pain reduction used for muscle aches, joint aches, toothaches, headaches, sore throat, menstrual cramps and many more.

Ibuprofen works by blocking the signals in the body, which produces pain. When cells in your body are injured or damaged, they release prostaglandins.

Ibuprofen(Advil) is a non-selective inhibitor of an enzyme called COX. The inhibition of COX by Ibuprofen lowers the level of prostaglandins, reducing the pain in the body. (KANTOR, T.G., 1979)

Valium-reduces Anxiety, and the depressant drug

Valium is the brand name of Diazepam, which belongs to the drug class Benzodiazepines. Valium is a prescription medicine that means if you want to buy Valium you will need a prescription from a doctor.

Valium is used to treat anxiety, relieve muscle spasms, prevent seizures, etc. But it is generally prescribed for Anxiety.

Valium, which is a benzodiazepine, works by increasing the activity of neurotransmitters called GABA in the brain. The whole process takes place in the central nervous system.

Neurotransmitters are natural body chemicals messengers that transmit messages between nerve cells to muscle.

Gamma-aminobutyric acid(GABA) which is a neurotransmitter that acts as a natural nerve-calming agent.

Thus, Valium works by regulating the GABA and relaxes the nerves and brain, which brings feelings of relaxation, reduces anxiety and induces sleep.

Now, I hope your doubt has been cleared by reading the above information about both medications, so let's focus on the interaction.

What is Drug Interaction?

When medication works properly, it boosts your health and helps you to feel better.

But when medication creates a problem, it doesn't mix well with something else you had consumed; it may be other medication, certain food or alcohol; when such a condition occurs, it is termed a drug interaction.

Drug interaction will stop the medication's working, and your medication will become less effective or too strong, which may trigger side effects. (Sohn, D.M., 1975)

Can you Take Ibuprofen and Valium Together?

There are various ways in which medications(drugs) can interact with each other. So the below stated information will help you to decide whether the combination of Ibuprofen and Valium is good or bad?

A total of 365 drugs interact with Ibuprofen, and 488 drugs interact with Valium, which includes various types of drug and food interaction.

What Are The Effects When They Are Combined Together?

Prescription drugs interact with OTC medication and give dangerous or unpleasant effects, which can be entirely unpredictable. Certain herbal supplements and foods can interact with common oral painkillers and give bad results.

Benzodiazepine is an anti-anxiety medication that works on the central nervous system by depressing or stopping the physical and emotional symptoms caused by anxiety and panic disorders.

It slows breathing rate and gives a feeling of relaxation and peace. Benzo can be addictive if used for long periods with other drugs, including certain painkillers.

Painkillers come in various forms.OTC medications like Ibuprofen and Acetaminophen are not addictive and generally don't produce any risk, but they can still show dangerous effects if mixed with Valium(Benzo).

The most significant danger occurs when Benzos are mixed with Opioid painkillers such as Co-codamol, Codeine, Vicodin, Oxycontin and Fentanyl. It makes you sleepy and slows the rate of breathing which can lead to coma or even death. So individuals may avoid the usage of such drugs together.

Caution Required When They Are Consumed Together

Ibuprofen is a non-opioid painkiller, so it doesn't show any dangerous effects, and it's fine if you consume it when needed with Diazepam, but more use of it together can create severe side effects.

Let's assume we use Ibuprofen to reduce pain and Valium for Anxiety. In that case, we may feel sleepy within 15 to 30 min after consuming Valium, and Ibuprofen takes 30 min to reduce the pain and inflammation.

We can take it together when needed but be careful with a few things.Consume recommended dosage of both medications; if from both drugs one drug dosage exceeds, it can lead to toxicity problems.

They do not have additive effects because they are from different medication classes, although sometimes they may complement each other.The kidney is mainly responsible for metabolising Ibuprofen, whereas benzo is broken down differently and metabolised by the liver, which is excreted in the urine.

Analysis of Study

This study states that 39 patients were under observation for the condition called orofacial pain(pain related to dental issues) 35 were women, and 4 were men, and the treatment was divided into four part-placebo, Diazepam, Ibuprofen, the combination of Diazepam and Ibuprofen.

The pain was decreased with a combination of Diazepam and Ibuprofen rather than other groups. Most significantly, Diazepam was more effective than Ibuprofen and other groups. Thus, this study states the effectiveness of Diazepam and Ibuprofen together for short-term usage and shows liability for side effects. (Singer E, Dionne R. J Orofac Pain. 1997)


We hope your doubts have been cleared by reading the blog, as it gives information about Ibuprofen and Valium and their effectiveness when combined together. No interactions were found between Ibuprofen and Valium, but their interactions are possible in some instances.

Both medications are opposite from each other and work differently, and have different effects on your body as Ibuprofen is a painkiller, while Valium is medication for anxiety. If we consume them together for a longer period and continuously, it may show dangerous side effects.

But it doesn't produce any risk if the combination is used for some time when the need arises. So it's always better to consult your healthcare provider before consuming them together. The combination effects of Ibuprofen and Valium depend on the duration of treatment and the working system of each person.

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