By Irfana
B.Sc (Psychiatry Ward)
22 November 2021 -
Medically reviewed by
D. Pharm
What are the Dangers of Mixing Clomipramine And Alcohol?
Table of Contents

Obsessive-compulsive disorder (OCD) is treated with clomipramine. Clomipramine belongs to the tricyclic antidepressant class of drugs. It works by raising serotonin levels in the brain, which are necessary for maintaining mental balance.

You might notice that clomipramine isn't working for you right away if you're taking it for depression. The effect can take a week or two to develop, and it can take 4-6 weeks to enjoy the full benefit. It would be best if you didn't stop taking it because you don't think it's working. You may also have upsetting thoughts while depressed, such as thoughts of self-harm or suicide. You must notify your doctor as soon as possible if this occurs.

When taking clomipramine, keep in mind that some adverse effects are possible. Before starting the prescription, talk to your doctor to determine how other medications interact with the one you've been prescribed. If you get a dry mouth as a side effect, eat ice chips or hard candies and drink plenty of water. Increase your fiber intake and exercise to help with side effects like constipation.

Furthermore, this drug should not be given to anyone else. If you forget to take a dose, take it as soon as you remember, or skip it if it's too near to the next planned dose. If you miss a dose, don't double it up, and don't stop taking clomipramine without first consulting your doctor. you can also purchase Clomipramine online from a certified online pharmacy, it is recommended to take a doctor's advice first. 

Clomipramine And Alcohol Together

Patients on clomipramine have experienced stomach trouble, dry mouth, and increased drowsiness and weariness, among other side effects. Mixing the drug with alcohol may cause patients to be less awake than usual due to these potential side effects.

Some individuals have reported increased anxiety symptoms while taking clomipramine and drinking alcohol, especially when they first start taking medicine. Furthermore, some patients had said that when they first started taking the medication or mixed it with alcohol, their initial OCD symptoms worsened. If any symptoms or side effects become unbearable, talk to your doctor or pharmacist about whether the medicine is good for you. 

While it has not been scientifically confirmed, some people have reported more blackouts after taking antidepressants and drinking alcohol. If this happens, book an appointment with a healthcare professional to discuss the appropriate medication and dosage for treating OCD symptoms. 

Scientific study on the comparison of the interaction between

Alcohol And Clomipramine Or Moclobemide In Healthy Subjects

In a double-blind parallel-group experiment with 24 healthy adults, the effects of clomipramine and moclobemide on alcohol were studied. Alcohol doses were pre-determined for each subject to create a blood alcohol content of 0.6 g/1 1 hour after consumption, and this individual alcohol dose was administered on test days.

Alcohol increased body sway, reduced crucial flicker fusion frequency, lengthened choice reaction time, hindered copying skills, degraded memory, and raised subjective sensations of satisfaction and tension. Clomipramine, in particular, exacerbated the effect of drugs on body sway caused by alcohol.

Clomipramine enhanced body sway and lengthened choice reaction time more than moclobemide, both with and without alcohol. In one of the memory tests utilized, clomipramine appeared to reduce alcohol-induced memory impairment. The clomipramine group experienced considerably more negative effects after consuming alcohol than the moclobemide group. Clomipramine, unlike moclobemide, caused a moderate but considerable decline in standing systolic blood pressure as well as a noticeable suppression of salivary secretion.

It may be concluded that there were no significant psychometric differences between moclobemide and clomipramine when it came to their interactions with alcohol. However, moclobemide lacked anticholinergic qualities and had fewer side effects than clomipramine.(Dwyer, S.M. and Rosenwasser, A.M., 1998)

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