By Irfana
B.Sc (Psychiatry Ward)
23 November 2021 -
Medically reviewed by
D. Pharm
Fluoxetine Vs Duloxetine
Table of Contents

Fluoxetine and Duloxetine, both these medications which belong to the SNRIs class of drugs. That is precisely used to treat mental health-related issues namely; depression, anxiety, OCD. To know further continue reading.

What is Fluoxetine?

Fluoxetine is prescribed to treat depression, obsessive-compulsive disorder, some eating disorders, and panic attacks. Fluoxetine is also used to relieve the symptoms of the premenstrual dysphoric disorder, including mood swings, irritability, bloating, and breast tenderness. It can also be used along with olanzapine to treat depression that did not respond to other medications and episodes of depression in people with bipolar I disorder. Fluoxetine is in a class of medications called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.

What is Duloxetine?

Duloxetine treats depression in adults and generalized anxiety disorder in adults and children seven years of age and older. Duloxetine is also used to treat pain and tingling caused because of diabetic neuropathy in adults and fibromyalgia in adults and children 13 years of age and older. It is also used to treat ongoing bone or muscle pain such as lower back pain or osteoarthritis in adults. Duloxetine is in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). It works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain. You need a prescription to buy duloxetine online from the certified pharmacy as it is not available over the counter. (Bergstrom, R., 2011).

How Fluoxetine Is Different From Duloxetine

Both fluoxetine and duloxetine are medications used to treat major depression and anxiety disorders. But fluoxetine and duloxetine work in the brain in different ways. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI), while Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI).

Fluoxetine primarily affects serotonin and is typically used for mood disorders. It may treat a wider variety of mood disorders than duloxetine, including bipolar disorder.

Duloxetine works on both serotonin and norepinephrine, so it has applications in treating some issues where fluoxetine wouldn’t work. Issues like nerve pain and fibromyalgia may be treated with duloxetine. 

Fluoxetine Dosage

Fluoxetine may be taken with or without food. Fluoxetine (Prozac) capsules, tablets, and liquid are usually taken once a day in the morning or twice a day, in the morning and at noon. Fluoxetine delayed-release capsules are generally taken once a week. Fluoxetine (Sarafem) is usually taken once a day, either every day of the month or on certain days of the month. It may take 4 to 5 weeks or longer before you feel the full benefit of fluoxetine. you can also buy Fluoxetine online from the certified online pharmacy but it is recommended to get doctor's prescription first. (Benfield, P., Heel, R.C., and Lewis, S.P., 1986).

Duloxetine Dosage

 It is usually taken once or twice a day with or without food. When duloxetine is used to treat generalized anxiety disorder, the pain of diabetic neuropathy, fibromyalgia, or ongoing bone or muscle pain, it is usually taken once a day with or without food. Take duloxetine at around the same time(s) every day. Duloxetine may help control your symptoms but will not cure your condition.

Some Severe Side Effects Of Fluoxetine

  • Rash
  • Hives or blisters
  • Itching
  • Fever
  • Joint pain
  • Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

Some Common Side Effects Of Fluoxetine

  • Nervousness
  • Anxiety
  • Difficulty falling asleep or staying asleep
  • Nausea
  • Diarrhea
  • Dry mouth
  • Heartburn

Some Serious Side Effects Of Duloxetine

  • Unusual bruising or bleeding
  • Pain in the upper right part of the stomach
  • Swelling of the abdomen
  • Itching
  • Yellowing of the skin or eyes
  • Dark-colored urine
  • Loss of appetite
  • Extreme tiredness or weakness

Some Common Side Effects Of Duloxetine

  • Unusual bruising or bleeding
  • Nausea or vomiting
  • Diarrhea
  • Acid Reflux or Heat Burn
  • Dry mouth

Warnings For Fluoxetine And Duloxetine Usage

Young adults up to 24 years of age who took fluoxetine during clinical studies became suicidal or thinking about harming themselves or planning or trying to do so. Children, teenagers, and young adults who take fluoxetine to treat depression or other mental illnesses. They may be more likely to become suicidal than those who do not take any antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant.


What's on your mind ?

Start a conversation ,Post with kindness.