By Irfana
B.Sc (Psychiatry Ward)
10 May 2022 -
Medically reviewed by
D. Pharm
Wellbutrin SR vs Wellbutrin XL
Table of Contents

Wellbutrin SR Vs Wellbutrin XL- Who Stands Last?

World Health organization data states that 3.8 percent of the world population suffers from depression and other serious mental issues. People are taking more effective steps to get better. Medications are becoming more effective in treating conditions. The evolution of scientific research has proved revolutionary methods to help people.

Wellbutrin is the product of such research. It is a medication used to treat depression, smoking habits etc. As we all know, medicines come in different types, and such a thing is also about Wellbutrin. Wellbutrin is not available over the counter in the United States. Buy Wellbutrin online  from a certified online pharmacy. (Huecker MR, Smiley A, Saadabadi A)

The Wellbutrin Sr and Wellbutrin XL create a state of puzzled thoughts between the peoples. 

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Who Is Better Wellbutrin SR Or Wellbutrin XL?

The difference lies in the name and the release duration of medicine. Wellbutrin SR and Wellbutrin XL, the word SR denotes sustained release and XL is called extended-release. Here we got a small yet detailed glimpse of treatment.

The sustained-release tablet is used for a short effect as per the condition, and vice versa for the extended-release tablets. A significant point in this is the active ingredients in these two medications are the same. It is called Bupropion in generic terms.

The XL extended-release tablets slowly release themselves as compared with Wellbutrin sustained-release tablets.

The half-life of Wellbutrin is 24 hours togetherly. It means the half-life of sustain release tablets is 12 hours due to their mechanism. Thus we can say that Sustained-release tablets work faster then extended-release tablets. So how much time does it take to eliminate from the system?


How Long Does Wellbutrin SR vs Wellbutrin Xl stay in the body?

You already know the half-life of Wellbutrin, so how much time does it take to eliminate it from the body completely. Wellbutrin SR and Wellbutrin XL can stay in the system for about 4-5 days. These numbers also can differ according to your prescribed dosing system.

The main difference in the complete elimination of Wellbutrin Sr And Wellbutrin XL depends on release. An XL dose can stay longer than an SR dose.

How Wellbutrin SR Vs Wellbutrin XL Works?

Mechanism of action is the same for this medicine as they belong to the same drug class. They work with the hormones like morphine, dopamine and make changes in neurotransmitters to drop the depression levels. Let’s know it in detail.

Wellbutrin Sustained-Release Tablet:

SR Tablets decrease the time of their release to increase the long-lasting effect. It delays the absorption time. There is also a covering of substances that helps to metabolize in the system slowly.

Wellbutrin Extended Release Tablet:

Extended-release tablets make the release duration even slower than sustained-release tablets. Hence the half-life also differs, and it also takes more time to eliminate from the system. Extended-release tablets are prescribed according to your severity of depression.  (Huecker MR, Smiley A, Saadabadi A)

Wellbutrin SR and Wellbutrin XL Can cause Weight Gain Or Weight Loss?

Antidepressants are closely associated with weight gain and weight loss. However, it is strictly not used for this purpose. Wellbutrin SR and Wellbutrin XL can simultaneously cause weight gain and weight loss, depending on the person.

It works with morphine and dopamine, which are related to appetite and eating behavior.

The FDA has not approved this medicine for weight.

Better is to use for the desired purpose.

Can Wellbutrin Cause Sexual Problems?

There are issues found in people regarding their sexual activities. However, they are not firm as pillars. It's not correctly stated that these people already had conditions or these medications have created interactions.

Issues like:

  • Painful Erection
  • Intercourse pain
  • Low sex drive
  • Premature Ejaculation etc.

Dosage Of Wellbutrin SR vs Wellbutrin XL?

Wellbutrin SR

For Adults- 150 mg tablets once a day should not exceed 200 mg.

For Children- Health experts' advice is mandatory.

Wellbutrin XL

For Adults- 150 mg once a day *4 can increase to 450 mg if tolerated by the body. Instead, 300mg is the strength of the average max dose.

For Children- Contact your doctor (Huecker MR, Smiley A, Saadabadi A)

Common Interactions Of Wellbutrin SR and Wellbutrin XL

Common interactions because the medicines have similar generic versions and the same active ingredient. There might be differences in unknown interactions according to your lifestyle, food, conditions etc. Below are the common interactions:

  • Benzodiazepines
  • Warfarin
  • Tizanidine
  • Rizatriptan
  • Zopiclone
  • Acetaminophen
  • Almotriptan etc.

Side effects of Wellbutrin SR and Wellbutrin XL

FDA Black Boxed warnings

FDA has issued warnings regarding this medicine. Due to the usage by teenagers and adults in depression and recreation. Suicidal thoughts and negative thinking can arise. Hence there are black-boxed warnings.


Two medicines can be differentiated but not competed. We can conclude that. Wellbutrin is an antidepressant that works on depression and seasonal affective disorder. Treatments are distinguished in their type, i.e. sustained-release and extended-release.

The answer lies in your condition, the prescribed type of medication, and how well the medicine works on you.

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